碳基纳米颗粒的吸入毒性研究进展
发布时间：2019-06-10 04:54
【摘要】：目的回顾石墨烯、碳纳米管、富勒烯C60等3种碳基纳米颗粒吸入毒性试验的过往文献资料并对其理化特性、吸入毒性、机制以及国内外研究现状作一综述,为开展有关试验研究提供参考。方法通过GCBI、Pubmed、万方数据库和中国知网收集过往相关文献。结果碳基纳米颗粒能够经呼吸道进入机体,并沉积下来,引发严重的肺部炎症、抑制细胞增殖、使肺清除功能下降、氧化损伤以及形成肺组织纤维化和肉芽肿等。结论碳基纳米颗粒的吸入毒性和作用机制备受关注,它对呼吸系统的影响不容忽视,有的职业工种是碳基纳米颗粒暴露的高危人群,在将纳米技术大规模应用于各个领域的同时也应该注意其安全性。
[Abstract]:Objective to review the previous literature of inhalation toxicity test of graphene, carbon nanotube and fullerene C60, and to review their physical and chemical properties, inhalation toxicity, mechanism and research status at home and abroad. It provides a reference for the relevant experimental research. Methods the relevant literature was collected through GCBI,Pubmed, Wanfang Database and China knowledge Network. Results carbon-based nanoparticles could enter the body through respiratory tract and precipitate, induce serious lung inflammation, inhibit cell proliferation, decrease lung clearance function, oxidative damage and formation of pulmonary fibrosis and granuloma. Conclusion the inhalation toxicity and mechanism of carbon nanoparticles have attracted much attention, and its effect on respiratory system can not be ignored. Some occupational jobs are at high risk of exposure to carbon nanoparticles. When nanotechnology is applied to various fields on a large scale, attention should also be paid to its safety.
【作者单位】： 贵州医科大学公共卫生学院;贵州省分析测试研究院;
【基金】：国家国际科技合作专项,项目编号,2015DFA41280 遗传资源与进化国家重点实验室开放课题(GREKF17-15) 环境化学与生态毒理学国家重点实验室开放基金(KF2016-21) 中央引导地方科技科技发展专项,黔科中引地[2016]4001号
【分类号】：R99
，
本文编号：2496184
[Abstract]:Objective to review the previous literature of inhalation toxicity test of graphene, carbon nanotube and fullerene C60, and to review their physical and chemical properties, inhalation toxicity, mechanism and research status at home and abroad. It provides a reference for the relevant experimental research. Methods the relevant literature was collected through GCBI,Pubmed, Wanfang Database and China knowledge Network. Results carbon-based nanoparticles could enter the body through respiratory tract and precipitate, induce serious lung inflammation, inhibit cell proliferation, decrease lung clearance function, oxidative damage and formation of pulmonary fibrosis and granuloma. Conclusion the inhalation toxicity and mechanism of carbon nanoparticles have attracted much attention, and its effect on respiratory system can not be ignored. Some occupational jobs are at high risk of exposure to carbon nanoparticles. When nanotechnology is applied to various fields on a large scale, attention should also be paid to its safety.
【作者单位】： 贵州医科大学公共卫生学院;贵州省分析测试研究院;
【基金】：国家国际科技合作专项,项目编号,2015DFA41280 遗传资源与进化国家重点实验室开放课题(GREKF17-15) 环境化学与生态毒理学国家重点实验室开放基金(KF2016-21) 中央引导地方科技科技发展专项,黔科中引地[2016]4001号
【分类号】：R99
，
本文编号：2496184
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