纳米颗粒形状影响其对肺表面活性剂的作用（英文）

发布时间：2019-06-20 04:51

【摘要】：肺表面活性剂是纳米颗粒经呼吸途径进入人体的初始生物屏障,纳米颗粒与肺表面活性剂的相互作用直接决定纳米颗粒潜在的诊疗应用和毒性.虽然已有很多研究致力于优化纳米颗粒的理化性质以提高其输运和靶向特性,但是纳米颗粒的形状效应对其与肺表面活性剂相互作用的影响仍鲜有报道.本文运用粗粒度分子动力学的方法研究了纳米颗粒的形状效应对其与一种模型肺表面活性剂——DPPC磷脂单分子层膜的作用的影响.研究结果表明,吸气过程中(磷脂单分子层膜扩张过程),形状效应基本可以忽略;呼气过程中(磷脂单分子层膜压缩过程),不同形状的纳米颗粒表现出不同的跨膜能力对膜的结构扰动亦有所不同,其中棒状纳米颗粒具有最强的跨膜能力,同时对膜的结构扰动也最小.该研究结果对促进纳米颗粒的呼吸诊疗应用具有积极的作用.
[Abstract]:Pulmonary surfactants are the initial biological barrier for nanoparticles to enter the human body through respiratory pathway. The interaction between nanoparticles and pulmonary surfactants directly determines the potential diagnosis, treatment and toxicity of nanoparticles. Although many studies have been devoted to optimizing the physical and chemical properties of nanoparticles to improve their transport and targeting properties, the effect of the shape effect of nanoparticles on the interaction between nanoparticles and pulmonary surfactants is still rarely reported. In this paper, the effect of shape effect of nanoparticles on the interaction of nanoparticles with DPPC phospholipid monolayers, a model pulmonary surfactants, has been studied by means of coarse-grain molecular dynamics. The results show that the shape effect can be ignored in the inspiratory process (phospholipid monolayer expansion process), and in the exhalation process (phospholipid monolayer compression process), the structure disturbance of the membrane is also different by the different transmembrane ability of the nanoparticles with different shapes, among which the rod nanoparticles have the strongest transmembrane ability and the least disturbance to the structure of the membrane. The results show that the shape effect can be ignored in the inspiratory process (phospholipid monolayer expansion process), and in the exhalation process (phospholipid monolayer compression process), the structure disturbance of the nanoparticles with different shapes is also different. The results of this study play a positive role in promoting the application of respiratory diagnosis and treatment of nanoparticles.
【作者单位】： State
【基金】：supported by the National Basic Research Program of China (2011CB933503) the National Natural Science Foundation of China (61127002) the PhD Program Foundation of Ministry of Education of China
【分类号】：R96;TB383.1

【共引文献】