伏立康唑磺丁基醚-β-环糊精包合物体内药动学的对比研究
发布时间：2019-07-02 12:41
【摘要】：目的:自制伏立康唑磺丁基醚-β-环糊精包合物与注射用伏立康唑(VFEND~汶)大鼠体内药动学对比研究。方法:以VFEND~汶为对照,Wistar大鼠为受试动物,采用超高效液相-飞行时间质谱(U-HPLC/Q-TOF-MS)监测伏立康唑的血药浓度,计算药动学参数,对自制药与对照药的各药动参数进行独立样本双侧t检验。结果:自制药和对照药大鼠体内伏立康唑的消除半衰期(t1/2)分别为(2.099±0.202)h和(2.142±0.163)h,药物浓度-时间曲线下面积(AUC0-12)分别为(23.247±1.264)μg·h·mL~(-1)和(22.748±1.568)μg·h·mL~(-1)。结论:自制药与对照药的大鼠体内药动学行为相似,各药动学参数相近。
[Abstract]:Aim: to compare the pharmacokinetics of Voliconazole sulfonbutyl ether-尾-cyclodextrin inclusion complex and Voliconazole (VFEND~ Wen) rats for injection. Methods: VFEND~ and Wistar rats were used as control and Wistar rats as subjects. The blood concentration of Voliconazole was monitored by ultra-high performance liquid phase-time-of-flight mass spectrometry (U-HPLC/Q-TOF-MS). The pharmacokinetics parameters were calculated and the pharmacokinetics parameters of Vriconazole were tested by bilateral t-test of independent samples. Results: the elimination half-life (T1 鈮，
本文编号：2508936
[Abstract]:Aim: to compare the pharmacokinetics of Voliconazole sulfonbutyl ether-尾-cyclodextrin inclusion complex and Voliconazole (VFEND~ Wen) rats for injection. Methods: VFEND~ and Wistar rats were used as control and Wistar rats as subjects. The blood concentration of Voliconazole was monitored by ultra-high performance liquid phase-time-of-flight mass spectrometry (U-HPLC/Q-TOF-MS). The pharmacokinetics parameters were calculated and the pharmacokinetics parameters of Vriconazole were tested by bilateral t-test of independent samples. Results: the elimination half-life (T1 鈮，
本文编号：2508936
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