用非线性光谱从分子层面上研究药物与细胞膜的作用

发布时间：2019-07-22 11:11

【摘要】：本文阐明不同药物与细胞膜原位作用的分子机制。应用一种非线性光谱-和频振动光谱来研究抗菌药物分子以及氯丙嗪、金刚烷胺和美金刚与电中性和电负性模型细胞膜的相互作用。细胞膜的主要组成部分是膦脂双层膜,因而细胞膜可以被认为是一个界面。从分子层面上原位地在水溶液的环境下阐述了各种材料包括药物分子,纳米材料,高分子,生物大分子与膦脂双层膜作用的机制,本文从非线性光谱-和频振动光谱角度予以综述。揭示了不同药物分子与不同模型细胞膜的不同作用。如一、阐述了抗菌药物分子是怎样破坏模型细胞膜的;二、揭示了氯丙嗪、金刚烷胺和美金刚与不同电性模型细胞膜作用时的相同及不同之处。和频振动光谱已成为一种研究药物分子与细胞膜相互作用的有力工具,可望用于研究中药与细胞膜的相互作用。
[Abstract]:In this paper, the molecular mechanism of in situ interaction between different drugs and cell membrane was clarified. A nonlinear spectrum-sum frequency vibrational spectrum was used to study the interaction between antibacterial molecules and the cell membrane of chlorpromazine, amantadine and US dollars with electronegativity and electronegativity. The main component of the cell membrane is the phosphine bilayer membrane, so the cell membrane can be considered as an interface. The mechanism of interaction between various materials, including drug molecules, nanomaterials, polymers, biomolecules and phosphine bilayer films, is described in situ at the molecular level in aqueous solution. In this paper, the nonlinear spectrum-sum frequency vibrational spectra are reviewed. The different effects of different drug molecules and different models of cell membrane were revealed. For example, it expounds how antibacterial molecules destroy the cell membrane of the model; second, it reveals the same and different effects of chlorpromazin, amantadine and US dollars on the cell membrane of different electrical models. Sum frequency vibrational spectroscopy has become a powerful tool to study the interaction between drug molecules and cell membrane, and it is expected to be used to study the interaction between traditional Chinese medicine and cell membrane.
【作者单位】：美国密歇根大学化学系;
【基金】：美国海军研究项目(N0014-02-1-0832;N0014-03-1-0503;N0014-08-1-1211)
【分类号】：R96;O657.3

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