某肿瘤专科医院抗肿瘤药致不良反应报告309例分析

发布时间：2019-08-02 09:42

【摘要】：目的:了解抗肿瘤药致药品不良反应(ADR)的特点和发生规律,为临床安全使用抗肿瘤药提供参考。方法:采用回顾性研究方法,对某肿瘤专科医院2015年1-12月收集的309例抗肿瘤药致ADR报告进行统计、分析。结果:309例ADR患者中,女性(58.25%)多于男性(41.75%);40岁以上患者所占比例较高(78.64%);引发ADR的给药途径以静脉滴注为主(94.82%);严重的ADR 225例(72.82%);经停药或治疗后好转的有268例(86.73%)。309例ADR共涉及24种抗肿瘤药物,引发ADR最多的药品依次为多西他赛、顺铂和环磷酰胺;ADR累及器官/系统以造血系统最常见(64.24%),临床表现主要为骨髓抑制。结论:临床应加强抗肿瘤药的ADR监测,及时预防、发现和诊治抗肿瘤药引发的ADR,以减少对患者造成的伤害,保证药物治疗的安全、有效。
[Abstract]:Objective: to investigate the characteristics and occurrence of adverse drug reactions (ADR) induced by antineoplastic drugs, and to provide reference for the safe use of antineoplastic drugs in clinic. Methods: 309 cases of ADR caused by antineoplastic drugs collected from January to December 2015 in a tumor hospital were statistically analyzed. Results: among 309 patients with ADR, female (58.25%) was more than male (41.75%), the proportion of patients over 40 years old was higher (78.64%), the main route of ADR administration was intravenous infusion (94.82%), 225 cases of severe ADR (72.82%), and 225 cases of severe ADR (72.82%). There were 268 cases (86.73%) improved after withdrawal or treatment. 309 cases of ADR involved 24 kinds of antitumor drugs, the most common drugs causing ADR were docetaxel, DDP and cyclophosphamide, and the hematopoietic system involved in ADR was the most common (64.24%), and the main clinical manifestation was bone marrow suppression. Conclusion: in order to reduce the injury to patients and ensure the safety and effectiveness of drug treatment, ADR monitoring of antitumor drugs should be strengthened, timely prevention, detection and diagnosis and treatment of ADR, caused by antineoplastic drugs should be strengthened in order to reduce the injury to patients and ensure the safety and effectiveness of drug treatment.
【作者单位】：广西医科大学附属肿瘤医院临床药学科;广西医科大学药学院;
【基金】：广西壮族自治区卫生厅课题项目(No.Z2014256)
【分类号】：R979.1

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