布洛芬缓释胶囊的制备及体外释放考察

发布时间：2019-08-12 14:37

【摘要】：目的:制备布洛芬缓释微丸,并研究其体外释放行为。方法 :采用离心流化包衣锅粉末层集工艺制备布洛芬缓释微丸,并对最终成品进行体外释放考察。结果:缓释胶囊批间及批内重复性较好,其体外释放行为释放符合一级释药方程,溶出曲线同市售"芬必得"相似。结论:本法制备的布洛芬缓释胶囊缓释效果好,工艺可行。
[Abstract]:Objective: to prepare ibuprofen sustained-release pellets and study its release behavior in vitro. Methods: ibuprofen sustained release pellets were prepared by centrifugal fluidization coating pot powder layer collection process, and the release of the final product in vitro was investigated. Results: the reproducibility between batches and intra-assay of sustained-release capsules was good, and the release behavior in vitro was in accordance with the first-order release equation, and the dissolution curve was similar to that of "Fenbid". Conclusion: the sustained release effect of ibuprofen sustained release capsule prepared by this method is good and the process is feasible.
【作者单位】：南京正大天晴制药有限公司;江苏省中医药研究院;
【分类号】：R943

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