环己胺的微生物代谢及相关氧化酶的研究进展

发布时间：2019-08-12 15:08

【摘要】：环己胺氧化酶属于一种胺氧化酶,目前仅对动植物体内的胺氧化酶进行了系统研究,但对于不同微生物来源的环己胺氧化酶了解不够广泛。在微生物代谢途径中,参与上游代谢的基因具有丰富的多样性,而参与下游代谢途径的基因模块在不同的微生物中相对保守。因此,研究微生物代谢环己胺的关键是探讨催化环己胺生成环己酮的环己胺氧化酶的催化机制。该文综述了目前国内外微生物降解环己胺的研究进展,介绍了环己酮单加氧酶和环己胺氧化酶在有机胺的微生物代谢途径研究中的作用,并对其潜在应用前景进行了展望。
[Abstract]:At present, only a systematic study of amine oxidase in animals and plants has been carried out, but it is not widely known for different microbial sources. In microbial metabolic pathway, the genes involved in upstream metabolism are rich in diversity, while the gene modules involved in downstream metabolic pathway are relatively conservative in different microorganisms. Therefore, the key to study the metabolism of Cyclohexylamine by microorganisms is to explore the catalytic mechanism of Cyclohexylamine Oxidase catalyzed by Cyclohexylamine to Cyclohexanone. In this paper, the research progress of microbial degradation of Cyclohexylamine at home and abroad is reviewed, the role of Cyclohexanone monooxygenase and Cyclohexylamine Oxygenase in the study of microbial Metabolism Pathway of Organic Amine is introduced, and its potential application prospect is prospected.
【作者单位】： 兵器工业卫生研究所毒理学评价中心;武汉轻工大学生物与制药工程学院;
【分类号】：R994.6
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本文编号：2525789