Neuroprotective effects of atorvastatin against cerebral isc

发布时间：2020-12-14 18:14

　　Cerebral ischemia triggers secondary ischemia/reperfusion injury and endoplasmic reticulum stress initiates cell apoptosis. However, the regulatory mechanism of the signaling pathway remains unclear. We hypothesize that the regulatory mechanisms are mediated by the protein kinase-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α in the endoplasmic reticulum stress signaling pathway. To verify this hypothesis, we occluded the middle cerebral artery in rats to establish focal cereb... 

【文章来源】：Neural Regeneration Research. 2015年08期

【文章页数】：6 页

【文章目录】：
Introduction
Materials and Methods
    Establishing cerebral ischemia/reperfusion model
    Drug administration
    TTC staining of brain infarct volume
    Transmission electron microscopy observation of the ultrastructure of the rat brain
    Western blot analysis of PERK, phosphorylated e IF2αand caspase-3 expression in rat brain tissue infarction side
    Statistical analysis
Results
    Atorvastatin decreased brain infarct volume in rats with cerebral ischemia/reperfusion injury
    Atorvastatin improved ultrastructure of brain tissue in rats with cerebral ischemia/reperfusion injury
    Atorvastatin reduced caspase-3, phosphorylated e IF2and PERK expression in infarcted brain tissue of rats with cerebral ischemia/reperfusion injury
Discussion


【参考文献】：
期刊论文
[1]针刺对戊四唑诱发惊厥大鼠海马葡萄糖调节蛋白78和C/EBP同源蛋白表达的影响[J]. 杨帆,马允,昂文平,陈浩,杜卫东,吴生兵,吕磊,张道芹.  针刺研究. 2014(04)



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