阿司匹林致老年人早期胃黏膜损伤相关因素研究
发布时间:2021-09-22 13:09
目的观察合并服用血管紧张素受体阻滞剂(ARB)、血管紧张素转化酶抑制剂(ACEI)或他汀类药物的老年人因长期应用阿司匹林致早期胃黏膜损伤的临床和相关因素。方法回顾性分析,选取2013—2018年解放军总医院长期应用100 mg阿司匹林且合并服用ACEI/ARB或他汀类药物的老年人467例,按照胃镜结果分为胃黏膜正常组125例,慢性胃炎组199例和胃黏膜糜烂组143例。对患者的临床特征和影响ACEI/ARB和他汀类药物吸收的SLCO1B1基因多态性进行分析。结果与胃黏膜正常组比较,肾小球滤过率下降[(66.5±24.4)ml·min·1.73 m-2比(70.9±18.5)ml·min·1.73 m-2,OR=5.06,95%CI:2.14~11.51,P<0.01]是慢性胃炎组和胃黏膜糜烂组患者慢性胃炎危险因素;年龄[(78.5±10.1)岁比(71.5±9.6)岁,OR=1.33,95%CI:1.04~2.87,P<0.05]、胃/十二指肠溃疡史[14.0%(20/143)比5.6%(7/125),OR=2.41,95%CI:1.08~5.01,P<0.05]、未应...
【文章来源】:中华老年医学杂志. 2020,39(07)北大核心CSCD
【文章页数】:5 页
【参考文献】:
期刊论文
[1]Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients[J]. Lin-yong XU~2,Yi-jing HE~3,Wei ZHANG~3,Sheng Deng~4,Qing LI~3,Wei-xia ZHANG~3,Zhao-qian LIU~3,Dan WANG~3,Yuan-feiHUANG~3,Hong-hao ZHOU~(3,5),Zhen-qiu SUN~(2,5)~2 Department of Epidemic and Health Statistics,School of Public Health,Central South University,Changsha 410078,China,~3 Pharmaeoge-netics Research Institute,Institute of Clinical Pharmacology,Central South University,Changsha 410078,China;~4 Affiliated XiangyaHospital of Central South University,Changsha 410078,China. Acta Pharmacologica Sinica. 2007(10)
本文编号:3403811
【文章来源】:中华老年医学杂志. 2020,39(07)北大核心CSCD
【文章页数】:5 页
【参考文献】:
期刊论文
[1]Organic anion transporting polypeptide-1B1 haplotypes in Chinese patients[J]. Lin-yong XU~2,Yi-jing HE~3,Wei ZHANG~3,Sheng Deng~4,Qing LI~3,Wei-xia ZHANG~3,Zhao-qian LIU~3,Dan WANG~3,Yuan-feiHUANG~3,Hong-hao ZHOU~(3,5),Zhen-qiu SUN~(2,5)~2 Department of Epidemic and Health Statistics,School of Public Health,Central South University,Changsha 410078,China,~3 Pharmaeoge-netics Research Institute,Institute of Clinical Pharmacology,Central South University,Changsha 410078,China;~4 Affiliated XiangyaHospital of Central South University,Changsha 410078,China. Acta Pharmacologica Sinica. 2007(10)
本文编号:3403811
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