全氟化合物与人类精液质量:LIFE研究

发布时间：2018-01-17 15:38

本文关键词：全氟化合物与人类精液质量:LIFE研究　出处：《环境与职业医学》2015年03期 　论文类型：期刊论文

【摘要】：[背景]虽然来自一般人群中男性的数据有限,但持久性环境化学物和精液质量之间关系的研究仍在不断发展之中。[目的]研究全氟化学物(PFCs)和501对计划怀孕的夫妇中男性伴侣的精液质量之间的关系。[方法]采用基于人群的抽样策略,从2005—2009年在两个美国地理区域内招募了501对停止避孕措施的夫妇。首先进行基线采访和人体测量学评估,随后采集血液样本,用串联质谱法定量7种血清全氟化学物(全氟磺酸、全氟羧酸和全氟磺酰胺)的含量。在基线期和约1个月后收集男性的精液样本。精液样本用冰袋贮存并运送,并在收集后的第二天进行分析。用线性回归估计自然对数转换的PFC浓度每增加一个单位各精液参数的差异,分析中校正了混杂因素,并用重复测量的精液样本建模。敏感性分析包括采用最优的Box-Cox转换精液质量终点指标。[结果]6种PFCs[2-(N-甲基全氟辛烷亚磺酰氨基)乙酸乙酯(Me-PFOSA-Ac OH)、全氟癸酸甲酯(PFDe A)、全氟壬酸甲酯(PFNA)、全氟辛烷磺酰胺(PFOSA)、全氟辛烷磺酸(PFOS)和全氟辛酸(PFOA)]均与Box-Cox变换前17种精液质量终点指标有关联。PFOSA与精子头部面积和周长较小、DNA染色比例较低以及双头和未成熟精子的比例更高有关联。PFDe A、PFNA、PFOA以及PFOS均与精子尾部卷曲比例较低有关联。[结论]部分全氟化物与一些精液质量终点指标有关联,PFOSA最为显著,但观察到的结果有不同。
[Abstract]:[Background although data from men in the general population are limited, studies on the relationship between persistent environmental chemicals and semen quality are still evolving. [Aim] to study the relationship between perfluorinated chemicals PFCs) and semen quality of male partners in 501 couples planning to conceive. [Methods A population-based sampling strategy was used to recruit 501 couples who stopped contraception from 2005 to 2009 in two geographic areas of the United States. Baseline interviews and anthropometric assessments were performed. Then blood samples were collected and seven serum perfluorinated chemicals (perfluorosulfonic acid) were measured by tandem mass spectrometry. Content of perfluorocarboxylic acid and perfluorosulfonamide. Semen samples from men were collected during the baseline period and about one month later. Semen samples were stored and transported in ice bags. On the second day after collection, the linear regression was used to estimate the difference of semen parameters per unit of the natural logarithmic conversion PFC concentration, and the confounding factors were corrected in the analysis. The sensitivity analysis included the optimal Box-Cox conversion of semen quality endpoints. [Results] six kinds of PFCs. [2-N- methyl perfluorooctane sulfonyl amino) ethyl acetate, Me-PFOSA-Ac OHH, methyl perfluorodecanoate, methyl perfluorodecanoate, methyl perfluorononate, methyl perfluorononate (PFNA). Perfluorooctanesulfonamide (PFOSA). Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoate (PFOAA)] were associated with 17 semen quality endpoints before Box-Cox transformation. PFOSA was associated with small head area and circumference of spermatozoa. The lower proportion of DNA staining and the higher ratio of double head and immature spermatozoa. PFDe Agna PFNAA PFOA and PFOS were all associated with lower crimp ratio of spermatozoa tail. [Conclusion: some perfluorides are most significantly associated with some semen quality endpoints, but the observed results are different.
【分类号】：R114
【正文快照】： 原文详见:Environmental Health Perspectives,123(1):57-63.全氟化合物与人类精液质量:LIFE研究@Germaine M.Buck Louis @Zhen Chen @Enrique F.Schisterman @Sungduk Kim @Anne M.Sweeney @Rajeshwari Sundaram @Courtney D.Lynch @Robert E.Gore-Langton @Dana Boy

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