不同物理化学性质纳米颗粒的血脑屏障通透机制及毒性影响研究进展

发布时间：2018-02-11 02:56

本文关键词： 纳米颗粒纳米药物物理化学性质血脑屏障中枢神经系统毒性风险　出处：《药物分析杂志》2015年08期 　论文类型：期刊论文

【摘要】：如何透过血脑屏障一直是纳米颗粒药物研究的热点和难点。本文查阅了1996年到2015年发表的48篇与纳米颗粒透过血脑屏障相关的重要SCI文献。总结了纳米颗粒透过血脑屏障的不同机制,包括被动扩散、透过细胞间隙和细胞转胞吞等。根据纳米颗粒独特的物理化学性质,详细综述了颗粒大小、表面带电、表面修饰等不同物理化学性质对纳米颗粒透过血脑屏障的影响,以及纳米颗粒对血脑屏障的潜在毒性风险。本文阐释了不同物理化学性质的纳米颗粒如何与血脑屏障相互作用进入大脑,为未来合理设计纳米颗粒,预测其在大脑的分布、生物相互作用和毒性风险提供理论支持。
[Abstract]:How to penetrate blood-brain barrier (BBB) has always been a hot and difficult point in drug research of nanoparticles. From 1996 to 2015, 48 important SCI documents related to the passage of nanoparticles through BBB were reviewed, and the permeation of nanoparticles through BBB was summarized. Different mechanisms of the blood-brain barrier, According to the unique physical and chemical properties of nanoparticles, the particle size and surface charge are reviewed in detail. Effects of different physical and chemical properties, such as surface modification, on the passage of nanoparticles through the blood-brain barrier, And the potential toxic risk of nanoparticles to blood-brain barrier. This paper explains how different physical and chemical properties of nanoparticles interact with blood-brain barrier into the brain to design nanoparticles reasonably in the future and predict their distribution in the brain. Biological interaction and toxicity risk provide theoretical support.
【作者单位】：中国食品药品检定研究院国家药物安全评价监测中心药物非临床安全评价研究北京市重点实验室;
【基金】：国家自然科学基金“磁性纳米粒蓄积诱导ROS激活自噬杀伤胶质瘤细胞的机制初探”(No.81401517)
【分类号】：R114;TB383.1

【共引文献】