职业性铝接触对作业工人心理、神经行为、认知及自主神经功能的影响

发布时间：2018-03-21 10:49

本文选题：铝　切入点：神经行为　出处：《上海交通大学学报(医学版)》2015年02期 　论文类型：期刊论文

【摘要】：目的探讨职业性铝接触对作业工人心理、神经行为、认知及自主神经功能的影响。方法从广西某大型铝厂选取110名男性铝作业工人为接触组,并从铝厂下属的服务公司中以接触组的年龄和文化程度构成匹配选取110名工人设为对照组。采用世界卫生组织推荐的神经行为核心测试方法对工人的心理情感和神经行为进行测试,利用简易智力状态量表(MMSE)评估认知功能,并检查自主神经功能改变。同时监测作业环境和工人血清、尿液样本中铝含量。结果配料、电解和铸造3个车间空气中铝的平均浓度分别为(6.45±1.23)、(7.02±1.45)和(6.95±1.86)mg/m3,明显高于对照组环境铝浓度(F=7.463,P0.001);接触组工人的血清和尿液铝含量亦均显著高于对照组(P0.05);情感状态问卷调查结果显示,接触组"困惑-迷茫"和"紧张-焦虑"得分值均明显高于对照组(P0.05),而其余指标的差异无统计学意义(P0.05);神经行为功能检测发现,简单反应时、数字译码、正确打点数和打点总数均显著低于对照组(P0.05),而其余指标的差异无统计学意义(P0.05);接触组MMSE评分总分及地点定向、语言即刻记忆、注意和计算、短程记忆、言语表达的评分及最大与最小R-R间隔比值(Rmax∶Rmin)均明显低于对照组(P0.05);工龄10年工人在地点定向、语言即刻记忆、注意和计算、短程记忆、语言理解和言语表达方面的分值均明显低于工龄5年受试者(P0.05)。结论职业性铝接触可以引起作业工人出现明显的心理状态、神经运动速度、准确性、协调能力及副交感神经调节功能的改变。
[Abstract]:Objective to investigate the effects of occupational aluminum exposure on psychological, neurobehavioral, cognitive and autonomic nervous function of workers exposed to aluminum. Methods 110 male aluminum exposed workers were selected from a large aluminum factory in Guangxi as exposure group. 110 workers were selected as the control group according to the age and educational level of the exposure group in the service company of the aluminum factory. The neurobehavioral core test method recommended by the World Health Organization (WHO) was used to test the psychological and emotional status of the workers. Neurobehavioral tests, MMSE was used to assess cognitive function and to check the changes of autonomic nervous function. At the same time, the contents of aluminum in working environment and workers' serum and urine samples were monitored. The average concentrations of aluminum in the air of electrolysis and casting workshops were 6.45 卤1.23 卤7.02 卤1.45) and 6.95 卤1.86 mg / m ~ (3), respectively, which were significantly higher than those of the control group (F _ (7.463) P _ (0.001)). The serum and urine aluminum contents of the exposed workers were also significantly higher than those of the control group (P 0.05). The scores of "bewilderment" and "tension anxiety" in the contact group were significantly higher than those in the control group (P 0.05), but there was no significant difference in the other indexes (P 0.05). The correct points and the total number of points were significantly lower than those of the control group (P 0.05), but there was no significant difference in the other indexes (P 0.05). The total score and location orientation of MMSE score, language immediate memory, attention and calculation, and short range memory in the contact group were all significantly lower than those in the control group. The scores of speech expression and the ratio of maximum to minimum R-R interval (Rmax: Rmin) were significantly lower than those of the control group (P 0.05). The scores of language comprehension and speech expression were significantly lower than those of the subjects with 5 years of service (P 0.05). Conclusion Occupational aluminum exposure can cause mental state, nerve movement speed and accuracy of workers exposed to occupational aluminum. The change of coordination ability and parasympathetic regulation function.
【作者单位】：右江民族医学院公共卫生与管理学院;
【基金】：国家自然科学基金(81360438,81360423) 广西自然科学基金(2013GXNSFAA019239,2014GXNSFAA118145) 广西教育厅广西高校科研项目(2013YB181)~~
【分类号】：R135

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