辐射从业人员丙氨酸转氨酶与谷氨酰转肽酶升高的危险因素分析

发布时间：2018-04-13 07:09

本文选题：电离辐射 + 丙氨酸转氨酶　；参考：《现代预防医学》2017年14期

【摘要】：目的探讨职业低剂量电离辐射从业人员肝功能指标丙氨酸转氨酶(ALT)与谷氨酰转肽酶(GGT)异常升高的危险因素。方法收集2015年成都市513名放射从业者一般人口学、辐射暴露及职业健康体检的ALT与GGT资料。采用t检验、方差分析、χ~2检验、多因素Logistic回归等方法进行统计分析。结果多因素Logistic回归分析显示:男性比女性更容易出现ALT(OR=4.07,P0.05)和GGT(OR=3.62,P0.05)升高;从事放射诊断的从业者比其他工种具有更高的ALT(OR=2.59,P0.05)和GGT(OR=5.11,P0.05)升高风险;BMI越高,ALT和GGT升高的风险就越大,从事放射诊断以及同位素工种且超重或肥胖的从业者比BMI正常且为其他辐射暴露的从业者,出现ALT升高的风险更高;从事放射诊断且BMI高于正常的职业人员有更高的GGT升高的风险。结论低剂量电离辐射从业人员ALT与GGT升高主要与性别、工种和BMI有关,男性、从事放射诊断且为高BMI者有更高的ALT与GGT升高风险。
[Abstract]:Objective to investigate the risk factors of abnormal elevation of alanine aminotransferase (alt) and glutamyl transpeptidase (GGT) in workers with low dose ionizing radiation.Methods ALT and GGT data of 513 radiation workers in Chengdu in 2015 were collected.T test, ANOVA, 蠂 2 test and multivariate Logistic regression were used for statistical analysis.Those engaged in radiological diagnosis and isotopic work who were overweight or obese had a higher risk of increased ALT than those who had normal BMI and were exposed to other radiation exposures;People who performed radiologic diagnostics and whose BMI was higher than normal had a higher risk of increased GGT.Conclusion the increase of ALT and GGT in low dose ionizing radiation workers is mainly related to sex, type of work and BMI. The higher risk of ALT and GGT is in men, who are engaged in radiology diagnosis and who are high BMI.
【作者单位】：四川大学华西公共卫生学院(华西第四医院);成都市疾病预防控制中心职业病防治科;
【基金】：四川大学大学生创新创业训练计划(项目编号:201610611923) 成都市科技惠民技术研发项目(项目编号:2014-HMO1-00396-SF)
【分类号】：R146

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