非生物降解型及生物降解型长效皮下埋植避孕剂的理论研究与应用进展

发布时间：2018-04-24 11:48

  本文选题：避孕 + 避孕器械　； 参考：《中国组织工程研究》2017年22期

【摘要】：背景:皮下埋植避孕剂是一种新型的避孕方法,目前已在全世界推广使用。目的:论述非生物降解型及生物降解型长效皮下埋植避孕剂的发展现状,对其优缺点进行探讨。方法:由第一作者用计算机检索中国知网、万方数据库、Pub Med数据库1967至2015年收录的有关文献,中文检索词为"埋植避孕剂、非生物降解、生物降解",英文检索词为"contraceptive implants,non-biodegradable,biodegradable"。共检索到文献240篇,选取符合要求的70篇进行综述。结果与结论:长效皮下避孕埋植剂通过局部毛细血管进入血液循环系统,避免了肠胃吸收,提高了药物的生物利用度,同时降低了药物的不良反应。根据药物载体的性能分为非生物降解和可生物降解两类。非生物降解埋植剂已被广泛应用,但因其非降解特性,致使不被机体吸收或代谢,需二次手术取出;生物降解型埋植剂药物释放完毕后,可生物降解的材料也基本降解,但由于材料本身特性所导致的缺陷限制了其应用,因此,需要寻找更加适合的生物降解型缓释载体。
[Abstract]:Background: subcutaneous implant contraceptive is a new contraceptive method, which has been widely used all over the world. Aim: to discuss the development of non-biodegradable and biodegradable long-acting subcutaneous implants and their advantages and disadvantages. Methods: the first author searched the literature collected from 1967 to 2015 with the Chinese key words of "buried contraceptive, non-biodegradable, biodegradable" and "contraceptive implants non-biodegradable biodegradable" by the computer search of China Zhiwang, Wanfang Med database from 1967 to 2015, and the Chinese key words were "contraceptive implants, non-biodegradable, biodegradable", and the Chinese key words were "implant contraceptive, non-biodegradable, biodegradable". A total of 240 articles were retrieved and 70 articles were reviewed. Results & conclusion: the long-term subcutaneous contraceptive implants enter the blood circulatory system through local capillaries, thus avoiding gastrointestinal absorption, increasing the bioavailability of drugs and reducing adverse drug reactions. According to the performance of drug carrier, it can be divided into two categories: non-biodegradable and biodegradable. Non-biodegradable implants have been widely used, but because of their non-degradable properties, they are not absorbed or metabolized by the body and need to be removed by secondary surgery. After the release of biodegradable implants, biodegradable materials are basically degraded. However, due to the defects caused by the properties of the material, it is necessary to find a more suitable biodegradable sustained-release carrier.
【作者单位】： 辽宁省计划生育科学研究院国家卫生和计划生育委员会生殖健康与遗传医学重点实验室;郑州澍青医学高等专科学校;
【基金】：国家自然科学基金(51503093) 辽宁省科学事业公益研究基金(2015001007) 辽宁省博士科研启动基金(201501116) 沈阳市科技攻关项目(F16-205-1-37)~~
【分类号】：R169.41
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本文编号：1796495