核桃对发育期小鼠认知功能的改善作用

发布时间：2018-05-02 09:36

本文选题：核桃 + 发育期小鼠　；参考：《营养学报》2015年02期

【摘要】：目的探讨核桃补充饮食对发育期小鼠认知功能的影响。方法初断乳昆明小鼠60只,体质量11~14g,分为:对照(常规饲料)、3%核桃和6%核桃(在常规饲料里核桃的配比分别为3%、6%)三组,分别采用旷场箱、避暗箱及八臂迷宫检测小鼠的自发活动、被动逃避能力及空间学习记忆能力,对比研究核桃对小鼠认知功能的改善作用。结果核桃干预对小鼠的摄食行为和体质量无影响。与对照组比,3%、6%核桃干预后小鼠的自主活动能力提高(P0.05);3%核桃组探索活性增强(P0.05),6%核桃组探索活性亦有增强趋势。八臂迷宫测试中,三组的总探索时间、参考记忆错误次数和工作记忆错误次数随天数增加均呈下降趋势。两个核桃干预组的参考记忆、工作记忆错误次数明显少于对照组(P0.05),探索时间明显缩短(P0.05)。结论核桃干预6w后,可使小鼠的自发活动能力增强、空间学习记忆能力显著提高,提示核桃能够明显改善发育期小鼠的认知功能。
[Abstract]:Objective to investigate the effect of walnut supplementary diet on cognitive function in developing mice. Methods Sixty newly weaned Kunming mice were divided into three groups: control group (3% walnut and 6% walnut) and control group (3% walnut and 6% walnut in the normal diet) were divided into three groups, which were divided into three groups: control group (3% walnut and 6% walnut). The spontaneous activity, passive escape ability and spatial learning and memory ability of mice were detected by avoiding dark box and eight arm labyrinth. The effects of walnut on cognitive function of mice were compared. Results Walnut intervention had no effect on feeding behavior and body mass of mice. Compared with the control group, the autonomous activity of mice treated with 6% P0.05% walnut was increased, and the exploring activity of P0.05 + 3% walnut group was enhanced. The exploring activity of P0.05 + 6% walnut group also showed a tendency to increase. In the eight-arm maze test, the total exploration time, the number of reference memory errors and the number of working memory errors decreased with the increase of the number of days. The number of working memory errors in the two walnut intervention groups was significantly lower than that in the control group (P 0.05), and the exploration time was significantly shortened. Conclusion the ability of spontaneous activity and spatial learning and memory were enhanced after 6 weeks of walnut intervention, suggesting that walnut could obviously improve the cognitive function of developing mice.
【作者单位】：军事医学科学院卫生学环境医学研究所;河北养元智汇饮品股份有限公司;
【基金】：河北养元营养研究基金
【分类号】：R151

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