重金属重点防控区儿童血镉水平与肾功能损伤的研究

发布时间：2018-09-01 10:36

【摘要】：目的探讨某国家级重金属污染重点防控区儿童血镉水平及其与肾功能损伤的关系。方法于2012年7月在某重金属重点防护区域(n=203)和非污染区(n=218)各选择1所小学作为研究现场,采用分层抽样方法抽取两所学校三~五年级学生进行问卷调查,并采集静脉血和晨尿,以电感耦合等离子体质谱法测定全血中镉水平,检测尿肌酐、视黄醇结合蛋白(RBP)和β2-微球蛋白(β2-MG)浓度。结果儿童血镉浓度范围为0.11~2.33μg/L,污染区和对照区儿童血镉中位数分别为0.51和0.32μg/L,污染区高于对照区,差异具有统计学意义(P0.05);单因素分析结果显示,父母文化程度和家庭年收入较高的儿童血镉水平较低(P0.05);多重线性回归结果表明,在重金属重点防控区生活的儿童血镉水平较高(P0.05);污染区儿童尿β2-MG和RBP浓度均高于对照区,差异具有统计学意义(P0.05);随着儿童静脉血镉浓度的增加,尿β2-MG和RBP呈上升趋势,尿β2-MG、RBP浓度与血镉呈正相关(P0.05)。结论该重金属重点防护区域儿童处于高镉负荷状态,可能影响肾近曲小管重吸收功能。
[Abstract]:Objective to study the relationship between blood cadmium level and renal function injury in a national heavy metal pollution prevention and control area. Methods in July 2012, a primary school was selected from one primary school in a key heavy metal protection area (NX203) and a non-contaminated area (NN218) as the study site. Stratified sampling was used to select the students in grade 3 ~ 5 of two schools to conduct a questionnaire survey, and venous blood and morning urine were collected. The levels of cadmium in whole blood, urinary creatinine, retinol binding protein (RBP) and 尾 2-microglobulin (尾 2-MG) were measured by inductively coupled plasma mass spectrometry (ICP-MS). Results the range of blood cadmium concentration in children was 0.11 ~ 2.33 渭 g / L, and the median of blood cadmium in contaminated area and control area were 0.51 and 0.32 渭 g / L, respectively, the difference was statistically significant (P0.05). The results of multiple linear regression showed that the blood cadmium levels of children living in the heavy metal control areas were higher (P0.05); the urinary 尾 2-MG and RBP concentrations of children in polluted areas were higher than those in control areas. The difference was statistically significant (P0.05); with the increase of blood cadmium concentration in children, urinary 尾 2-MG and RBP showed an upward trend, urine 尾 2-MGG RBP concentration was positively correlated with blood cadmium (P0.05). Conclusion Children in this heavy metal protected area are under high cadmium loading, which may affect the reabsorption function of proximal convoluted tubules.
【作者单位】：深圳市疾病预防控制中心;深圳市宝安区疾病预防控制中心;深圳市福田区疾病预防控制中心;
【基金】：原卫生部卫生行业科研专项(201002001)
【分类号】：R114

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