三聚氰胺对不同周龄BALC小鼠的肾毒性

发布时间：2018-10-22 09:35

【摘要】：为研究三聚氰胺对不同周龄BALC小鼠肾毒性的差异情况,将3、6、12周龄SPF级BALC雌性小鼠各60只随机分成3组,分别对照组和20、500 mg/kg三聚氰胺染毒组,每组20只。采用自由饲喂法进行染毒,连续染毒28 d。测定小鼠的血清肌酐、尿素氮浓度。结果显示,与对照组比较,各剂量三聚氰胺染毒组BALC小鼠的血清肌酐和尿素氮浓度均较高,除12周龄20 mg/kg组外,差异均有统计学意义(P0.01);且随着三聚氰胺染毒剂量的升高,不同周龄BALC小鼠的血清肌酐和尿素氮浓度均呈上升趋势。提示三聚氰胺对小鼠的肾毒性随着周龄的增大而减弱。
[Abstract]:In order to study the renal toxicity of melamine to BALC mice of different weeks, 60 female SPF female mice of 12 weeks old were randomly divided into three groups: control group and 20500 mg/kg melamine group, 20 mice in each group. The method of free feeding was used for 28 days. Serum creatinine and urea nitrogen concentration in mice were determined. The results showed that the concentrations of serum creatinine and urea nitrogen in BALC mice exposed to melamine were higher than those in control group, except for 20 mg/kg group at 12 weeks old, the difference was statistically significant (P0.01), and the concentration of serum creatinine and urea nitrogen increased with the increase of melamine exposure dose. Serum creatinine and urea nitrogen concentrations in BALC mice at different weeks showed an increasing trend. The results suggest that the nephrotoxicity of melamine to mice decreases with the increase of age.
【作者单位】：齐鲁医药学院医学检验系;
【基金】：山东省教育厅自然科学类项目(J12LK53)
【分类号】：R114

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