膳食味精对普通雌鼠、哺乳母鼠及其子代身体健康影响的研究
发布时间：2018-11-10 08:56
【摘要】：味精常作为鲜味添加剂用于烹饪美食中。味精经胃肠道代谢后分解成的谷氨酸对机体有重要的生理作用,味精对机体可能存在损害作用,部分人在食用味精后会出现“中国餐馆综合症”。本研究在实验动物基础饲料中添加了1%味精.(MSG),观察味精对普通雌鼠和哺乳母鼠及其子代的影响,为公众合理膳食味精提供科学依据。 第一部分：1%MSG对普通雌鼠Lee's指数(P0.05)、BMI(P0.01)心和肾的脏器指数(P0.05)有显著影响,增加了白细胞、淋巴细胞绝对值(P0.01)、红细胞(P0.05)和血红细胞量(P0.01),升高了ALP、CR和UI值(P0.05),但是提高了普通雌鼠血清游离氨基酸、必需氨基酸和非必需氨基酸的含量(P0.05)。1%MSG对母鼠Lee's指数(P0.05)和BMI(P0.01)有显著影响,对血小板分布宽度有影响(P0.05),使生化指标ALP、CR和UI出现显著性升高(P0.05),使血浆中总氨基酸、必需氨基酸、非必需氨基酸的含量下降。 第二部分：普通雌鼠1%MSG实验组肝脏细胞核偏小且不规整,肝板排列稍微凌乱,脂肪粒较空白对照组偏多,其间炎性细胞浸润。哺乳母鼠1%MSG实验组肝脏细胞不太规正,肝板排列稍微凌乱,肝窦不算均匀,肝糖元和脂肪粒较空白对照组偏多,可见炎性细胞散布其中。表明1%MSG对肝脏可能造成损伤。 普通雌鼠和哺乳母鼠1%MSG实验组肾小球肥大,细胞增多,肾小囊较厚,内皮细胞排列不规整,有脱落现象。表明1%MSG对肾脏可能造成损伤。 普通雌鼠实验组的十二指肠、空肠和回肠的粘膜完整,绒毛排列整齐,杯状细胞清晰可见；与空白对照组相比,其绒毛更长,排列更加紧密。实验组粘膜厚度比空白对照组高,但无显著性差异。哺乳母鼠性状相同。表明1%MSG对肠道无损伤,并有促进生长的作用。 第三部分：对实验组和空白组所生子鼠进行观察,子鼠Lee's指数和BMI指数存在显著性差异,表明后代产生向心性肥胖；在神经行为学实验中,实验组和对照组有显著差异。说明1%MSG对子鼠感觉运动能力有一定影响；在旷场实验中,实验组子鼠跨越格子数、站立次数降低,排便数和捋毛次数升高,表明味精能导致子鼠的自主探索运动活动能力减弱,并且有焦虑情绪；Morris水迷宫实验空白组与实验组差异不显著,表明味精对子代学习记忆能力无影响。
[Abstract]:Monosodium glutamate is often used as a flavor additive in cooking. Glutamic acid decomposed from MSG after gastrointestinal metabolism has important physiological effects on the body. MSG may damage the body, and some people will develop "Chinese Restaurant Syndrome" after eating MSG. In this study, 1% monosodium glutamate (. (MSG),) was added to the basic diet of experimental animals to observe the effect of monosodium glutamate (MSG) on female mice, lactating mothers and their offspring, and to provide scientific basis for a reasonable diet of MSG. The first part: 1%MSG had a significant effect on the Lee's index (P0.05), BMI (P0.01) of heart and kidney (P0.05), increased the absolute value of leukocyte and lymphocyte (P0.01). RBC (P0.05) and erythrocyte count (P0.01) increased ALP,CR and UI values (P0.05), but increased serum free amino acids in normal female rats. The contents of essential amino acids and non-essential amino acids (P0.05). 1%MSG had significant effects on Lee's index (P0.05) and BMI (P0.01), and on platelet distribution width (P0.05), which resulted in the biochemical index ALP,. CR and UI increased significantly (P0.05), which decreased the contents of total amino acids, essential amino acids and non-essential amino acids in plasma. The second part: the liver nucleus of 1%MSG group was small and irregular, the liver plate was disorganized, the fat granules were more than that of the blank control group, and the inflammatory cells infiltrated. In 1%MSG group, the liver cells were irregular, liver plates were disordered, hepatic sinusoids were not uniform, liver glycogen and fat granules were more than those in blank control group, inflammatory cells were scattered among them. This suggests that 1%MSG may damage the liver. The glomerular hypertrophy, increase of cells, thicker renal capsule, irregular arrangement of endothelial cells and abscission of endothelial cells were observed in normal female and lactating female 1%MSG experimental groups. This suggests that 1%MSG may damage the kidney. The mucous membrane of duodenum jejunum and ileum of normal female rats was complete the villi were arranged neatly and goblet cells were clearly visible. Compared with the blank control group the villi were longer and more closely arranged. The mucosal thickness in the experimental group was higher than that in the blank control group, but there was no significant difference. The traits of lactating female rats are the same. The results showed that 1%MSG had no injury to intestine and promoted growth. In the third part, the Lee's index and BMI index of the offspring of the experimental group and the blank group were observed, which indicated that the offspring had concentric obesity, and there were significant differences between the experimental group and the control group in neurobehavioral experiment. The results showed that 1%MSG had a certain effect on the sensory and motor ability of the mice. In the open field experiment, the number of mice crossing the grid, the number of standing decreased, the number of defecation and the number of hair smoothing increased in the experimental group, which indicated that monosodium glutamate (MSG) could lead to the weakening of autonomous exploring activity and anxiety. There was no significant difference between the blank group of Morris water maze experiment and the experimental group, which indicated that monosodium glutamate had no effect on learning and memory ability of offspring.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R153.1
本文编号：2321977
[Abstract]:Monosodium glutamate is often used as a flavor additive in cooking. Glutamic acid decomposed from MSG after gastrointestinal metabolism has important physiological effects on the body. MSG may damage the body, and some people will develop "Chinese Restaurant Syndrome" after eating MSG. In this study, 1% monosodium glutamate (. (MSG),) was added to the basic diet of experimental animals to observe the effect of monosodium glutamate (MSG) on female mice, lactating mothers and their offspring, and to provide scientific basis for a reasonable diet of MSG. The first part: 1%MSG had a significant effect on the Lee's index (P0.05), BMI (P0.01) of heart and kidney (P0.05), increased the absolute value of leukocyte and lymphocyte (P0.01). RBC (P0.05) and erythrocyte count (P0.01) increased ALP,CR and UI values (P0.05), but increased serum free amino acids in normal female rats. The contents of essential amino acids and non-essential amino acids (P0.05). 1%MSG had significant effects on Lee's index (P0.05) and BMI (P0.01), and on platelet distribution width (P0.05), which resulted in the biochemical index ALP,. CR and UI increased significantly (P0.05), which decreased the contents of total amino acids, essential amino acids and non-essential amino acids in plasma. The second part: the liver nucleus of 1%MSG group was small and irregular, the liver plate was disorganized, the fat granules were more than that of the blank control group, and the inflammatory cells infiltrated. In 1%MSG group, the liver cells were irregular, liver plates were disordered, hepatic sinusoids were not uniform, liver glycogen and fat granules were more than those in blank control group, inflammatory cells were scattered among them. This suggests that 1%MSG may damage the liver. The glomerular hypertrophy, increase of cells, thicker renal capsule, irregular arrangement of endothelial cells and abscission of endothelial cells were observed in normal female and lactating female 1%MSG experimental groups. This suggests that 1%MSG may damage the kidney. The mucous membrane of duodenum jejunum and ileum of normal female rats was complete the villi were arranged neatly and goblet cells were clearly visible. Compared with the blank control group the villi were longer and more closely arranged. The mucosal thickness in the experimental group was higher than that in the blank control group, but there was no significant difference. The traits of lactating female rats are the same. The results showed that 1%MSG had no injury to intestine and promoted growth. In the third part, the Lee's index and BMI index of the offspring of the experimental group and the blank group were observed, which indicated that the offspring had concentric obesity, and there were significant differences between the experimental group and the control group in neurobehavioral experiment. The results showed that 1%MSG had a certain effect on the sensory and motor ability of the mice. In the open field experiment, the number of mice crossing the grid, the number of standing decreased, the number of defecation and the number of hair smoothing increased in the experimental group, which indicated that monosodium glutamate (MSG) could lead to the weakening of autonomous exploring activity and anxiety. There was no significant difference between the blank group of Morris water maze experiment and the experimental group, which indicated that monosodium glutamate had no effect on learning and memory ability of offspring.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R153.1
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