不同剂量率的低剂量X射线诱导早熟染色体断片的剂量效应关系

发布时间：2018-11-16 06:43

【摘要】：为了解决低传能线密度辐射诱发的染色体畸变存在剂量率效应的问题,以便较为准确地估算不同剂量率受照人员的吸收剂量。用3种不同照射剂量率的低剂量X线照射离体人外周血,CA诱导染色体早熟,收获早熟凝集染色体,采用盲法阅片,计数染色体断片数和畸变细胞数,分析畸变率与照射剂量之间的关系,分别拟合不同剂量率的剂量效应曲线和数学模型。结果表明,在剂量率一定的情况下,各剂量点的染色体断片率随吸收剂量增加而增加。同一剂量点不同剂量率射线诱发的染色体断片率随剂量率的增加而增加,剂量率效应明显。因此在估算低传能线密度辐射的吸收剂量时,应该考虑剂量率效应,根据受照情况尽量选择剂量率相近的剂量-效应关系曲线进行估算,从而使结果更为准确。
[Abstract]:In order to solve the problem that the chromosome aberration induced by low energy transmission line density radiation has dose rate effect, the absorbed dose of persons exposed to different dose rates can be estimated more accurately. Human peripheral blood was irradiated with three kinds of low dose X-rays at different dose rates. CA induced precocious chromosomes and harvested precocious agglutinated chromosomes. The number of chromosomal fragments and aberrant cells were counted by blind reading method. The relationship between distortion rate and irradiation dose was analyzed and the dose-effect curves and mathematical models of different dose rates were fitted respectively. The results show that the chromosome fragment rate of each dose point increases with the increase of the amount of absorbent at a given dose rate. The chromosome fragment rate induced by different dose rates at the same dose point increased with the increase of dose rate, and the dose rate effect was obvious. Therefore, the dose rate effect should be taken into account in estimating the absorbed dose of low energy transmission linear density radiation, and the dose-effect curve with similar dose rate should be selected as far as possible according to the radiation exposure, so as to make the results more accurate.
【作者单位】：山东省医学科学院放射医学研究所;黄石第二医院;
【基金】：山东省自然科学基金(项目编号ZR2010HQ061)
【分类号】：R144.1

【共引文献】