伴同疗法和含铋剂四联方案根除幽门螺杆菌的成本—效果分析

发布时间：2018-04-28 23:01

本文选题：幽门螺杆菌 + 伴同疗法　；参考：《新疆医科大学》2017年硕士论文

【摘要】：目的:评价伴同疗法和含铋剂四联方案根除幽门螺杆菌的成本-效果。方法:选取2015年12月至2016年12月于新疆维吾尔自治区人民医院消化科门诊就诊患者,行14C尿素呼气试验证实为Hp感染156例,随机分为A、B两组,A组76例,B组80例。A组用伴同疗法:雷贝拉唑20 mg,每日2次、甲硝唑400mg,每日2次、克拉霉素500mg,每日2次、阿莫西林1000mg,每日2次;B组铋剂四联疗法:雷贝拉唑20 mg,每日2次、胶体果胶铋胶囊150mg,每日3次、克拉霉素500mg,每日2次、阿莫西林1000mg,每日2次。两组服药疗程均为14天。停药4周后复查14C尿素呼气试验,并对比两组方案的成本-效果。结果:A、B两组成本分别为1082.63元、1114.05元,ITT分析根除率分别为82.9%、86.3%,两组根除率间差异无统计学意义(P=0.467)。两组成本-效果比分别为13.05、12.91。结论:伴同疗法与含铋剂四联方案在根除Hp方面经济性和有效性相当,我国可作为一线方案推荐使用。
[Abstract]:Objective: To evaluate the cost effectiveness of the quadruple therapy and bismuth containing regimen in the eradication of Helicobacter pylori. Methods: 156 cases of Hp infection were confirmed from December 2015 to December 2016 at the the Xinjiang Uygur Autonomous Region people's hospital. 156 cases of Hp infection were confirmed as A, B two, 76 cases in group A, and 80.A groups in group B. Therapy: rizole 20 mg, 2 times a day, metronidazole 400mg, 2 times daily, clarithromycin 500mg, 2 times daily, amoxicillin 1000mg, 2 times a day; group B bismuth 20 mg, 2 times a day, Colloidal Bismuth Pectin Capsules 150mg, 3 times daily, clarithromycin 500mg, amoxicillin 1000mg, 2 times a day. The medication course of group two was 14 days. After 4 weeks of withdrawal, the 14C urea breath test was rechecked and the cost effect of the two groups was compared. Results: the cost of A and B two groups was 1082.63 yuan and 1114.05 yuan respectively. The eradication rates of the ITT analysis were 82.9%, 86.3% and two, respectively (P=0.467). The cost effect ratio of the two groups was 13.05,12.91. conclusion, with the same therapy and bismuth containing agents, respectively. The quadruple program is very economical and effective in eradicating Hp. China can be recommended as a first-line project.

【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R57

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