中国和巴基斯坦帕金病的研究及其差异
发布时间：2019-05-16 00:42
【摘要】：目的：原发性帕金森病在世界各地都有发生。本病普遍存在于各个国家各个社会阶层,帕金森病的发病率和患病率随着年龄的增加而增加,目前在65岁以上人群里发病率为1%。预计到2040年,帕金森病以及其他神经变性病(如阿尔兹海默病和运动神经元病等)将超过癌症成为第二大常见死亡原因,而且到2040年帕金森病的发病率将增加4倍。在美国将近有100万人患有帕金森病,而且每年约有65000人被新诊断为帕金森病。全世界每年用于帕金森病治疗的费用大约需要270亿元。在欧洲和美国都有一些关于帕金森病花费的研究,但是这种研究在巴基斯坦还较少见。帕金森病病程进行性加重,其发病率逐渐增加,这给社会、健康保健提供者、患者自己以及家庭带来了巨大的经济负担。张和罗马综述了世界各地帕金森病的发病情况,报道说中国、日本和非洲的帕金森病患病率明显低于西方国家。根据对巴基斯坦三个不同地区逐家逐户的调查,巴基斯坦的帕金森病患病率较低。巴基斯坦没有统一的,大规模的,全国性的有关帕金森病的发病率和患病率的流行病学数据。对帕金森患者的治疗和管理的主要目的是延长寿命和限制运动障碍的进展。现在健康护理专业人员确信,医疗保健的目标是不仅是照顾病人和提高生存率,而且也要提高他们的生活质量。生活质量越来越被认为健康护理的重要方面,因为它体现了患者自身角度对他们健康的看法。像帕金森这样的慢性疾病的病人的生活质量包括他们的症状和身体机能也包括心理变化,我研究了中国和巴基斯坦这两个种族的帕金森病患者,对他们的临床特征,发病年龄,治疗方法,治疗花费和生活质量进行了评估和比较。 方法：对病人的研究和报告来自中国和巴基斯坦两个国家。帕金森患者分别来自中国山东省济南市齐鲁医院和巴基斯坦的拉合尔医院。在门诊对患者的临床特征,实验室检查和其他调查进行记录和分析。然后从两个医院分别选取50例患者。记录下完整的处方信息和治疗的花费。我们一共调查了100名患者。来自中国和巴基斯坦各50例患者,其中巴基斯男性42例,女性8例,中国男性44例,女性6例。巴基斯坦患者的平均年龄为56岁,中国的为51.18岁。 结果：我们发现与中国一样,86%的巴基斯坦患者在50或60岁左右发病。患者来就诊时疾病的平均病程在中国为6.9年在巴基斯坦为7.15年。治疗的花费在中国为53.51美元而巴基斯坦为26.79美元。强直,运动迟缓,震颤,缺乏表情,原始反射,难以进行精细的工作和行走困难是巴基斯坦和中国患者是最常见的临床症状。在中国,大部分患者在I或II期(Hoehn-Yahr分级)疾病阶段初诊,而在巴基斯坦,患者第一次来看病的阶段大多在疾病2.0-2.5期。在中国患者以单侧症状为主,这在巴基斯坦是比较少见的。 结论：：震颤,僵直,行走困难,运动迟缓,难以进行精细的做工是帕金森病最常见的临床特征。疾病的严重程度随疾病的持续时就爱你而增加。虽然在巴基斯坦的成本管理比中国少,但是生活质量比中国好。认知功能障碍并不少见,与这些患者的疾病的病程和发病年龄相关。在中国患者的平均寿命较高是由于较高的生活质量和与巴基斯坦相比较好的社会状况,因为去医院就诊的巴基斯坦患者主要是农民,退休工人,所以病人常常不安规定服药。在巴基斯坦中年以后容易患帕金森病,患者大多为50岁以上的人。发病的平均年龄是60岁。然而,有些巴基斯坦医师在过去几年的报道中注意到“早发性帕金森病’,估计5%到10%的患者在40岁以下。治疗处方包括息宁(75%左旋多巴+25%苄丝肼)仍然是在巴基斯坦治疗帕金森病的唯一药物。PD的管理也要求治疗相关的问题和并发症如吞咽困难,便秘,性功能障碍,体位性低血压等,这些症状容易被患者忽视。
[Abstract]:Objective: The primary Parkinson's disease has occurred in all parts of the world. The incidence and prevalence of Parkinson's disease are increased with the increase of age, and the incidence of Parkinson's disease is 1% in the population over the age of 65. It is expected that in 2040, Parkinson's disease and other neurodegenerative diseases, such as Alzheimer's disease and motor neuron disease, will be more than the second most common cause of death, and the incidence of Parkinson's disease will increase by four times in 2040. In the United States, nearly 1 million people have Parkinson's disease, and about 65,000 people are diagnosed with Parkinson's disease every year. The cost of the worldwide treatment of Parkinson's disease is about $22.7 billion a year. There are some studies on parkinson's disease in both Europe and the United States, but the study is rare in Pakistan. The progressive increase in the course of Parkinson's disease, with a gradual increase in the incidence of Parkinson's disease, has brought enormous economic burden to society, health care providers, patients themselves and the family. Zhang and Rome reviewed the incidence of Parkinson's disease in various parts of the world and reported that the prevalence of Parkinson's disease in China, Japan and Africa was significantly lower than that of Western countries. The prevalence of Parkinson's disease in Pakistan is low based on a case-by-case survey of three different parts of Pakistan. There is no uniform, large-scale, nationwide epidemiological data on the incidence and prevalence of Parkinson's disease in Pakistan. The primary objective of the treatment and management of Parkinson's is to extend the life and limit the progression of dyskinesia. Health care professionals are now convinced that the goal of health care is not only to care for patients and to improve survival, but also to improve their quality of life. The quality of life is increasingly being considered as an important aspect of health care, as it represents the patient's own view of their health. The quality of life of patients with chronic diseases like Parkinson's disease, including their symptoms and physical functions, also includes psychological changes, and I have studied patients with Parkinson's disease in both China and Pakistan, their clinical characteristics, the age of onset, and the methods of treatment, The treatment cost and quality of life were evaluated and compared. Methods: The study and report of the patient came from two countries in China and Pakistan The patients of Parkinson's disease are from the Qilu Hospital of Jinan, Shandong Province and the Lahore Medical College in Pakistan, respectively. The hospital. Record and score the clinical features, laboratory and other investigations of the patient in the clinic Analysis. Then select 50 patients from two hospitals. A. Record the complete prescription information and the cost of treatment Fee. We've been investigating a total of 100. People from 50 patients in China and Pakistan, including 42 male and 8 female,44 female,6 female The average age of patients in Pakistan is 56 years and China is 51.18. As a result, we found that, like China,86% of Pakistani patients were at 50 or 60 years of age The average course of the disease at the time of the patient's visit was 6.9 years in China and 7 in Pakistan. 15 years. The cost of treatment is $53.51 in China and 26.7 in Pakistan It is the most common presence of Pakistan and Chinese patients with rigidity, bradykinesia, tremors, lack of expression, original reflection, difficulty in fine work and walking. The symptoms of the bed. In China, most of the patients were first diagnosed at the stage I or II (Hoehn-Yahr), while in Pakistan, the first time the patient came to the hospital, most of the patients were in the disease version 2.0-2. .5. In Chinese patients with one-sided symptoms, this is the case in Pakistan It's rare. Conclusion: Tremor, rigidity, difficulty in walking, slow movement and difficulty in fine workmanship are the most common in Parkinson's disease. Clinical characteristics of the disease. The severity of the disease is dependent on the duration of the disease Love you. Although the cost management in Pakistan is less than China, the quality of life The amount is better than that of China. The cognitive impairment is not uncommon, and the course of the disease and the onset of the disease in these patients The age of the disease is related to the age of the disease. The higher life expectancy in Chinese patients is due to the higher quality of life and the social situation in comparison to that of Pakistan, because the Pakistani patients who go to the hospital are mainly farmers and retired workers, so the patient often does not The patients with Parkinson's disease are prone to parkinson's disease after middle-age in Pakistan, with a majority of 50 patients The average year of the onset of the disease. The age was 60. However, some Pakistani doctors, in the past few years, noted that "early-onset Parkinson's disease ', estimated to be between 5 and 10% of patients, The treatment prescription, including Xining (75% levodopa + 25%), is still in the treatment of Parkinson's disease in Pakistan The management of PD also requires treatment-related problems and complications such as dysphagia, constipation, sexual dysfunction, orthostatic hypotension, etc.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R742.5
本文编号：2477888
[Abstract]:Objective: The primary Parkinson's disease has occurred in all parts of the world. The incidence and prevalence of Parkinson's disease are increased with the increase of age, and the incidence of Parkinson's disease is 1% in the population over the age of 65. It is expected that in 2040, Parkinson's disease and other neurodegenerative diseases, such as Alzheimer's disease and motor neuron disease, will be more than the second most common cause of death, and the incidence of Parkinson's disease will increase by four times in 2040. In the United States, nearly 1 million people have Parkinson's disease, and about 65,000 people are diagnosed with Parkinson's disease every year. The cost of the worldwide treatment of Parkinson's disease is about $22.7 billion a year. There are some studies on parkinson's disease in both Europe and the United States, but the study is rare in Pakistan. The progressive increase in the course of Parkinson's disease, with a gradual increase in the incidence of Parkinson's disease, has brought enormous economic burden to society, health care providers, patients themselves and the family. Zhang and Rome reviewed the incidence of Parkinson's disease in various parts of the world and reported that the prevalence of Parkinson's disease in China, Japan and Africa was significantly lower than that of Western countries. The prevalence of Parkinson's disease in Pakistan is low based on a case-by-case survey of three different parts of Pakistan. There is no uniform, large-scale, nationwide epidemiological data on the incidence and prevalence of Parkinson's disease in Pakistan. The primary objective of the treatment and management of Parkinson's is to extend the life and limit the progression of dyskinesia. Health care professionals are now convinced that the goal of health care is not only to care for patients and to improve survival, but also to improve their quality of life. The quality of life is increasingly being considered as an important aspect of health care, as it represents the patient's own view of their health. The quality of life of patients with chronic diseases like Parkinson's disease, including their symptoms and physical functions, also includes psychological changes, and I have studied patients with Parkinson's disease in both China and Pakistan, their clinical characteristics, the age of onset, and the methods of treatment, The treatment cost and quality of life were evaluated and compared. Methods: The study and report of the patient came from two countries in China and Pakistan The patients of Parkinson's disease are from the Qilu Hospital of Jinan, Shandong Province and the Lahore Medical College in Pakistan, respectively. The hospital. Record and score the clinical features, laboratory and other investigations of the patient in the clinic Analysis. Then select 50 patients from two hospitals. A. Record the complete prescription information and the cost of treatment Fee. We've been investigating a total of 100. People from 50 patients in China and Pakistan, including 42 male and 8 female,44 female,6 female The average age of patients in Pakistan is 56 years and China is 51.18. As a result, we found that, like China,86% of Pakistani patients were at 50 or 60 years of age The average course of the disease at the time of the patient's visit was 6.9 years in China and 7 in Pakistan. 15 years. The cost of treatment is $53.51 in China and 26.7 in Pakistan It is the most common presence of Pakistan and Chinese patients with rigidity, bradykinesia, tremors, lack of expression, original reflection, difficulty in fine work and walking. The symptoms of the bed. In China, most of the patients were first diagnosed at the stage I or II (Hoehn-Yahr), while in Pakistan, the first time the patient came to the hospital, most of the patients were in the disease version 2.0-2. .5. In Chinese patients with one-sided symptoms, this is the case in Pakistan It's rare. Conclusion: Tremor, rigidity, difficulty in walking, slow movement and difficulty in fine workmanship are the most common in Parkinson's disease. Clinical characteristics of the disease. The severity of the disease is dependent on the duration of the disease Love you. Although the cost management in Pakistan is less than China, the quality of life The amount is better than that of China. The cognitive impairment is not uncommon, and the course of the disease and the onset of the disease in these patients The age of the disease is related to the age of the disease. The higher life expectancy in Chinese patients is due to the higher quality of life and the social situation in comparison to that of Pakistan, because the Pakistani patients who go to the hospital are mainly farmers and retired workers, so the patient often does not The patients with Parkinson's disease are prone to parkinson's disease after middle-age in Pakistan, with a majority of 50 patients The average year of the onset of the disease. The age was 60. However, some Pakistani doctors, in the past few years, noted that "early-onset Parkinson's disease ', estimated to be between 5 and 10% of patients, The treatment prescription, including Xining (75% levodopa + 25%), is still in the treatment of Parkinson's disease in Pakistan The management of PD also requires treatment-related problems and complications such as dysphagia, constipation, sexual dysfunction, orthostatic hypotension, etc.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R742.5
【共引文献】
相关期刊论文 前2条
1 王顺;戚秀杰;韩迪;;头部电针透穴疗法对帕金森病模型大鼠黑质TH及DAT基因表达的影响[J];中国针灸;2009年05期
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相关博士学位论文 前3条
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相关硕士学位论文 前2条
1 李伟平;构建重组大肠杆菌生物合成左旋多巴[D];江南大学;2005年
2 程宇核;电针对帕金森病模型大鼠黑质小胶质细胞及促炎性细胞因子的影响[D];湖北中医药大学;2010年
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