格列本脲原料药生产线产能提升研究
发布时间：2018-11-19 15:04
【摘要】：随着市场化三十余年的发展，中国制药产业经历了无数的竞争考验和市场洗礼，面临国内外新的竞争与机遇，中国制药企业如何继续谋求发展是目前的当务之急。但面对近年来人民币持续升值、原材料价格逐步攀升、劳动力成本日益上涨等问题，，无疑对制药企业的发展都造成了巨大的影响。如何提高企业生产效率，降低运营成本仍是当下各个企业要解决的重要问题。 本文以天津医药集团津康制药有限公司原料药车间的格列本脲生产线为研究对象，运用基于约束理论的DMAIC流程，对格列本脲原料药各生产工序的产能提升进行了详细的分析和研究。 本文首先根据生产现状找出影响系统产能的各种问题，定义出瓶颈工序；然后对其影响产品质量的各项指标进行量化，并建立回归模型，找出并确定较为合理的相关技术参数，通过有效的提升各工序产品质量，从而达到提升部分工序产能的目标；最后本着持续改进的原则，继续找出生产体系中新的问题，并加以改善，最终使格列本脲原料药的产能和原料成本等关键经济技术指标提升到一个较好的水平。 通过本文的研究成果，可为企业内部其他产品的生产起到良好的示范作用，从而带动企业整体生产效率的进一步提高，并使企业的管理水平更加科学和合理。
[Abstract]:With the development of marketization for more than 30 years, the Chinese pharmaceutical industry has experienced numerous competition tests and market baptism, facing new competition and opportunities at home and abroad. It is urgent for Chinese pharmaceutical enterprises to continue to seek development. But in the face of the appreciation of RMB in recent years, the rising price of raw materials and the rising labor cost, there is no doubt that the development of pharmaceutical enterprises has a huge impact. How to improve the production efficiency and reduce the operating cost is still an important problem to be solved by each enterprise. In this paper, the Glibenclamide production line in the raw material medicine workshop of Tianjin Pharmaceutical Group Jinkang Pharmaceutical Co., Ltd is taken as the research object, and the DMAIC process based on constraint theory is used. The production capacity of glibenclamide raw material was analyzed and studied in detail. Firstly, according to the current production situation, this paper finds out the various problems that affect the system capacity, and defines the bottleneck process. Then it quantifies the indexes that affect the product quality and establishes the regression model to find out and determine the more reasonable technical parameters to improve the product quality of each working procedure effectively so as to achieve the goal of increasing the production capacity of some processes. Finally, in line with the principle of continuous improvement, the new problems in the production system are found and improved, finally, the key economic and technical indexes such as the production capacity and raw material cost of glibenclamide are raised to a better level. Through the research results of this paper, it can play a good role in demonstrating the production of other products within the enterprise, thus driving the further improvement of the overall production efficiency of the enterprise, and making the management level of the enterprise more scientific and reasonable.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：TQ460.6;F426.72
本文编号：2342703
[Abstract]:With the development of marketization for more than 30 years, the Chinese pharmaceutical industry has experienced numerous competition tests and market baptism, facing new competition and opportunities at home and abroad. It is urgent for Chinese pharmaceutical enterprises to continue to seek development. But in the face of the appreciation of RMB in recent years, the rising price of raw materials and the rising labor cost, there is no doubt that the development of pharmaceutical enterprises has a huge impact. How to improve the production efficiency and reduce the operating cost is still an important problem to be solved by each enterprise. In this paper, the Glibenclamide production line in the raw material medicine workshop of Tianjin Pharmaceutical Group Jinkang Pharmaceutical Co., Ltd is taken as the research object, and the DMAIC process based on constraint theory is used. The production capacity of glibenclamide raw material was analyzed and studied in detail. Firstly, according to the current production situation, this paper finds out the various problems that affect the system capacity, and defines the bottleneck process. Then it quantifies the indexes that affect the product quality and establishes the regression model to find out and determine the more reasonable technical parameters to improve the product quality of each working procedure effectively so as to achieve the goal of increasing the production capacity of some processes. Finally, in line with the principle of continuous improvement, the new problems in the production system are found and improved, finally, the key economic and technical indexes such as the production capacity and raw material cost of glibenclamide are raised to a better level. Through the research results of this paper, it can play a good role in demonstrating the production of other products within the enterprise, thus driving the further improvement of the overall production efficiency of the enterprise, and making the management level of the enterprise more scientific and reasonable.
【学位授予单位】：天津大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：TQ460.6;F426.72
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相关期刊论文 前2条
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2 张艳,黄乾贵;优化方法在工程技术中的实际应用[J];煤矿机械;2003年11期
本文编号：2342703
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