顶端外胚层嵴对肢体发育的立体调控（英文）
发布时间：2021-10-21 06:33
理解胚胎肢体发育有助于更加全面地了解肢体的发生和分化,同时对于相关基因疗法和肢体再生具有临床指导意义。本文综述了顶端外胚层嵴（AER）参与胚胎肢体发育调控的研究进展及机理,重点总结了AER对肢体发育三个轴向的立体调控,包括基因表达调控、信号通路及相关调控中心,并进一步讨论了各信号中心之间的交互作用及现有研究待解决问题,从而加深对肢体发育异常、肢端异常等疾病的理解。
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2020,21(10)SCICSCD
【文章页数】：10 页
【文章目录】：
1 Introduction
2 Role of AER in proximodistal patterning
2.1 Current models for specifying positional in-formation in proximodistal patterning
2.2 Molecular and genetic bases of proximodistal patterning
2.3 Roles of FGF10 signalling in pre-AER and post-AER induction
3 Role of AER in anteroposterior patterning
4 Role of AER in dorsoventral patterning
5 Role of AER in shaping the developing limb
6 Signalling interactions across different signalling centres during limb development
7 Conclusions
Contributors
Compliance with ethics guidelines
本文编号：3448436
【文章来源】：Journal of Zhejiang University-Science B（Biomedicine & Biotechnology）. 2020,21(10)SCICSCD
【文章页数】：10 页
【文章目录】：
1 Introduction
2 Role of AER in proximodistal patterning
2.1 Current models for specifying positional in-formation in proximodistal patterning
2.2 Molecular and genetic bases of proximodistal patterning
2.3 Roles of FGF10 signalling in pre-AER and post-AER induction
3 Role of AER in anteroposterior patterning
4 Role of AER in dorsoventral patterning
5 Role of AER in shaping the developing limb
6 Signalling interactions across different signalling centres during limb development
7 Conclusions
Contributors
Compliance with ethics guidelines
本文编号：3448436
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