反相微乳液交联法制备葡聚糖水凝胶微球的粒径调控

发布时间：2018-01-16 19:10

本文关键词：反相微乳液交联法制备葡聚糖水凝胶微球的粒径调控　出处：《化工进展》2017年10期 　论文类型：期刊论文

【摘要】：基于天然高分子的水凝胶微球因具有良好的生物相容性,作为生物材料得到了广泛应用。本文采用反相微乳液交联技术制备了一系列葡聚糖水凝胶微球,并探讨了反相微乳液体系中表面活性剂的亲水亲油平衡值(HLB值)、乳化方式、水油相体积比(φ)、水相与表面活性剂的摩尔比(R0)等因素对该葡聚糖水凝胶微球形貌及粒径的影响情况。结果表明:采用环己烷(CYH)/Span 80-Tween 80/醛基化葡聚糖(Dex-CHO)乳液体系制备所得葡聚糖水凝胶微球的粒径在400nm~70μm之间可调;相对于机械搅拌乳化,超声波乳化条件下获得的凝胶微球具有更小的粒径,且当复配乳化剂m(Tween 80)/m(Span 80)=0.10、HLB值=5.27、φ=1/6时,获得的凝胶微球粒径最小(约422nm);葡聚糖凝胶微球的粒径随着R0值的增加呈现增大趋势。该葡聚糖水凝胶微球粒径可控,是一类天然高分子水凝胶,有望作为载体材料应用于生物医学领域。
[Abstract]:Hydrogel microspheres based on natural polymers have been widely used as biomaterials because of their good biocompatibility. A series of dextran hydrogel microspheres were prepared by reverse microemulsion crosslinking technique. The hydrophilic and lipophilic equilibrium value (HLB) of surfactant in inverse microemulsion system, the emulsification mode and the volume ratio of water to oil phase (蠁) were also discussed. The effect of water phase to surfactant molar ratio (R0) on the morphology and particle size of the dextran hydrogel microspheres was investigated. The diameters of dextran hydrogel microspheres prepared by rSpan 80-Tween 80 / Dex-CHO emulsion system are adjustable in the range of 400 nm or 70 渭 m. Compared with mechanical stirring emulsification, the gel microspheres obtained by ultrasonic emulsification have smaller particle size, and when mixed with emulsifier mween80 / mSpan 80 / m 0. 10, the gel microspheres obtained by ultrasonic emulsification have smaller particle size than those obtained by mechanical emulsification. When the HLB value is 5.27 and 蠁 ~ (-1 / 6), the particle size of the gel microspheres is the smallest (about 422nm). The diameter of dextran gel microspheres, which is a kind of natural polymer hydrogels, is expected to be used as carrier material in biomedical field because the diameter of dextran gel microspheres increases with the increase of R0.
【作者单位】：昆明理工大学化学工程学院;
【基金】：国家自然科学基金(51503090) 昆明理工大学自然科学基金(14118713)项目
【分类号】：O648.17
【正文快照】： 基于天然高分子材料的水凝胶因具有优良的生物安全性,作为生物材料得到了广泛的应用。葡聚糖是一种来源丰富的天然多糖材料,作为一种生物材料应用具有良好的生物相容性,而且具有容易获取、与药物亲和能力强,其长链上的活性基团极易进行修饰得到具有反应活性的葡聚糖衍生物,能

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