牺牲硅胶法制备烟酸分子印迹聚合物及其性能研究

发布时间：2018-01-27 13:14

本文关键词： 分子印迹聚合物牺牲载体烟酸硅胶　出处：《高校化学工程学报》2011年05期 　论文类型：期刊论文

【摘要】：选用薄层层析硅胶作为牺牲载体,以烟酸为模板分子,丙烯酰胺为功能单体,乙二醇二甲基丙烯酸酯为交联剂,合成了烟酸分子印迹聚合物(MIPs)。通过考察功能单体种类及用量、交联剂用量及硅胶用量确定了制备MIPs的最佳工艺条件,制备得到的MIPs吸附容量达到78.5μmol·g-1。以烟酰胺作为竞争底物考察MIPs的特异吸附性能,其分离因子达到2.76,分离因子比为2.14。重复耐用性实验表明,MIPs具有很好的耐用性能。通过扫描电子显微镜(SEM)对聚合物微观形貌进行表征,并以Scatchard分析法对其结合性能进行了研究。结果表明,与用传统本体聚合法制备的MIPs相比,以牺牲硅胶法合成的MIPs具有更好的特异吸附性能。
[Abstract]:TLC silica gel was used as sacrificial carrier, nicotinic acid as template molecule, acrylamide as functional monomer and ethylene glycol dimethacrylate as crosslinking agent. Niacin molecularly imprinted polymer (MIP) was synthesized. The optimum preparation conditions of MIPs were determined by investigating the kinds and amounts of functional monomers, the amount of crosslinking agent and the amount of silica gel. The adsorption capacity of the prepared MIPs was 78.5 渭 mol 路g-1.The specific adsorption performance of MIPs was investigated with nicotinamide as the competitive substrate, and the separation factor was 2.76. The separation factor ratio was 2.14.The repeated durability experiment showed that MIPs had good durability. The micromorphology of the polymer was characterized by scanning electron microscopy (SEM). The binding properties of MIPs were studied by Scatchard method. The results showed that compared with the MIPs prepared by traditional bulk polymerization method. The MIPs synthesized by sacrificial silica gel has better specific adsorption properties.
【作者单位】：浙江工业大学绿色化学合成技术国家重点实验室;
【基金】：浙江省自然科学基金资助(Y5100247)
【分类号】：O631.3
【正文快照】： 1前言烟酸又名尼克酸、维生素B5、维生素PP或称抗癞皮病维生素,是B族维生素中性质最稳定、化学结构最简单的一种。烟酸可通过抑制外周脂肪组织的脂解从而降低血浆低密度蛋白胆固醇和甘油三酯浓度,并可提高高密度蛋白胆固醇密度[1],从而具有很好的降脂药效。烟酰胺与烟酸同为B

【参考文献】