共缩聚法制备氨基化介孔硅及其对毒死蜱的缓释性能

发布时间：2018-03-10 10:17

本文选题：共缩聚法　切入点：介孔硅　出处：《农药学学报》2016年05期 　论文类型：期刊论文

【摘要】：通过化学修饰法对介孔硅(MCM-41)进行改性。以十六烷基三甲基溴化铵(CTAB)为模板剂、正硅酸乙酯(TEOS)为硅源、3-氨丙基三乙氧基硅烷(APTES)为改性剂,采用共缩聚法制备了氨基化介孔硅(NH2-MCM-41),并以毒死蜱为模型药物,制备了毒死蜱/氨基化介孔硅载药体系。利用X射线衍射(XRD)、氮气吸附-脱附、透射扫描电子显微镜(TEM)、扫描电子显微镜(SEM)、Zeta电位和傅里叶红外光谱(FTIR)对MCM-41和NH2-MCM-41的结构、形貌、Zeta电位和毒死蜱的负载情况进行了表征,考察了MCM-41和NH2-MCM-41对毒死蜱的吸附量和缓释性能,并着重探究了NH2-MCM-41与毒死蜱之间的作用力。结果表明:NH2-MCM-41和MCM-41均为有序的六方相介孔结构。MCM-41对毒死蜱的吸附量为106 mg/g,而NH2-MCM-41的最大吸附量为178 mg/g,且后者的吸附量随其Zeta电位值升高而增大。APTES的加入有利于改善MCM-41对毒死蜱的缓释性能;载药体系的释药行为可用Higuchi动力学模型来描述。
[Abstract]:The mesoporous silica (MCM-41) was modified by chemical modification. Using CTAB (hexadecyltrimethylammonium bromide) as template and ethyl orthosilicate (TEOS) as silicon source, 3-aminopropyltriethoxysilane (APTES) was used as modifier. The amino mesoporous silica (NH2-MCM-41) was prepared by co-condensation and chlorpyrifos was used as a model drug to prepare chlorpyrifos / amino mesoporous silicon-loaded system. The adsorption-desorption of chlorpyrifos by X ray diffraction (XRD) and nitrogen adsorption-desorption was used to prepare the chlorpyrifos / amino mesoporous silicon-loaded system. MCM-41 and NH2-MCM-41 were characterized by transmission scanning electron microscope (TEM), scanning electron microscope (SEM) and Fourier transform infrared spectroscopy (FTIR). The adsorption capacity and slow-release properties of MCM-41 and NH2-MCM-41 for chlorpyrifos were investigated. The interaction force between NH2-MCM-41 and chlorpyrifos is studied. The results show that the adsorption capacity of Chlorpyrifos is 106mg / g for NH2-MCM-41 and MCM-41 is ordered hexagonal mesoporous structure. The maximum adsorption capacity of NH2-MCM-41 is 178mg / g, and the adsorption capacity of the latter is with its Zeta. The increase of potential value and the addition of .APTES can improve the slow-release property of MCM-41 to chlorpyrifos. The drug release behavior of the drug delivery system can be described by Higuchi kinetic model.
【作者单位】：仲恺农业工程学院化学化工学院;
【基金】：国家自然科学基金(21576303) 广东省自然科学基金(2016A030313375) 广东省科技计划项目(2014A020208126) 广州市科技计划项目(201510010150) 广东省教育厅特色创新项目(2015KTSCX064)
【分类号】：TQ450.1

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