微乳液法制备磷酸八钙（OCP）、磷酸三钙（TCP）纳米粉体

发布时间：2018-04-25 05:33

本文选题：纳米磷酸八钙 + 纳米磷酸三钙　；参考：《成都理工大学》2011年硕士论文

【摘要】：磷酸八钙(Ca_8(HPO_4)_2(PO_4)·5H_2O,OCP)是牙齿和骨骼构成的主要成分之一,是羟基磷灰石的重要前驱体,具有良好的生物相容性和生物活性,是较好的骨替换材料;磷酸三钙(Ca3(PO4)2,TCP)具有与人体骨骼组织成分相似的矿物组成,具有良好的生物降解性、生物相容性和生物无毒性,当其植入人体后,降解出的Ca、P能进入活体循环系统形成新生骨。磷酸八钙和磷酸三钙用作组织修复材料,在骨修复方面有很好的应用前景。不同的制备方法对两者的性能及其应用有重要的影响。微乳液法是一种制备纳米粒子的新方法,因其可控制颗粒尺寸、形貌及比表面等而备受关注。本研究采用反相微乳液法仿生合成了OCP、TCP纳米粉体。制作了Triton X-100/正癸醇/异辛烷/水四组分体系相图。本文采用目视和电导测量相结合的研究方法,对Triton X-100/正癸醇/异辛烷/水四组分体系的结构进行了研究,探讨了不同油相、不同比例聚乙二醇辛基苯基醚和正癸醇、不同反应物浓度以及不同温度对该体系处于W/O结构时最大增溶水量及体系稳定性的影响,确定了反相微乳液法制备纳米磷酸八钙和纳米磷酸三钙的相图区域。以此区域下的反相微乳液为模板,通过改变不同的反应条件,成功合成了不同粒径和形貌的OCP和TCP纳米颗粒。通过透射电子显微镜(TEM)、X-射线衍射仪(XRD)、红外光谱仪(FTIR)等表征手段研究了产物颗粒尺寸、结构和形貌。其中OCP为棒状纳米颗粒,直径为20～50nm,长度为60～120nm;TCP为梭状纳米颗粒,直径为10～20nm,长度在80～110nm。讨论了不同热处理温度、不同水油比、不同陈化时间、不同搅拌时间以及溶液的不同pH值对OCP、TCP纳米颗粒形貌、尺寸以及结晶程度等性质的影响,结果表明改变水油比和搅拌时间可实现对纳米OCP、TCP颗粒尺寸的控制,而陈化时间对其影响不大,而溶液pH值的改变将会导致最终产物的改变。
[Abstract]:5H _ 2O _ 2O _ (OCPP) is one of the main components of teeth and bones, is an important precursor of hydroxyapatite, has good biocompatibility and bioactivity, and is a better bone replacement material. Tricalcium phosphate has mineral composition similar to that of human skeletal tissue, and has good biodegradability, biocompatibility and non-toxicity. When implanted into human body, the degraded CaP can enter the living body circulatory system to form new bone. Octadecalcium phosphate and tricalcium phosphate are used as tissue repair materials and have a good application prospect in bone repair. Different preparation methods have an important effect on their properties and applications. Microemulsion method is a new method for preparing nanoparticles, which has attracted much attention because of its controllable particle size, morphology and specific surface. In this study, OCP-TCP nano-powders were synthesized by inverse microemulsion method. The phase diagram of Triton X-100 / n-decanol / isooctane / water four-component system was prepared. In this paper, the structure of Triton X-100 / n-decanol / isooctane / water four-component system was studied by means of visual and conductance measurements. The different oil phase, different proportion of polyethylene glycol octyl phenyl ether and n-decanol were discussed. The effects of different reactants concentration and temperature on the maximum solubilization water content and the stability of the system at the W / O structure were investigated. The phase diagram of nanosized octadecalcium phosphate and nanometer tricalcium phosphate prepared by reverse microemulsion method was determined. OCP and TCP nanoparticles with different particle sizes and morphologies were successfully synthesized by changing the different reaction conditions and using reverse microemulsion in this region as template. The particle size, structure and morphology of the product were studied by means of TEM and FTIR. Among them, OCP is a rod shaped particle with a diameter of 20 ~ 50 nm, a length of 60 ~ 120 nm ~ (-1), a diameter of 10 ~ (20) nm and a length of 80 ~ (10) nm ~ (-1). The effects of different heat treatment temperature, different water / oil ratio, different aging time, different stirring time and different pH value of solution on the morphology, size and crystallization degree of TCP nanoparticles were discussed. The results show that the size of TCP nanoparticles can be controlled by changing water / oil ratio and stirring time, but aging time has little effect on it, and the change of pH value of solution will lead to the change of final product.
【学位授予单位】：成都理工大学
【学位级别】：硕士
【学位授予年份】：2011
【分类号】：TB383.1

【引证文献】