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凝胶模板法制备甘草次酸单分散微粒

发布时间:2018-12-11 18:20
【摘要】:目的:明确凝胶模板工艺过程中微粒粒径大小和不同溶剂体系对甘草次酸微粒性质的影响。方法:采用新型凝胶模板法,分别利用不同孔径模板和不同溶剂体系制备甘草次酸-PLGA微粒,扫描电镜观察其表面形态,测定载药量及包封率,比较体外释药特征。结果:所得微粒呈微小圆柱体,粒径均一、形态可控,载药量较高,改变粒径大小和溶剂体系可调节微粒体外释放度。结论:凝胶模板法微粒制备技术可精确控制微粒粒径和形态,适用溶剂广泛,有利于缓释微粒给药系统的释药调节。
[Abstract]:Aim: to investigate the effect of particle size and solvent system on the properties of glycyrrhetinic acid particles in gel template process. Methods: a new gel template method was used to prepare glycyrrhetinic acid-PLGA particles using different pore size templates and different solvent systems respectively. The surface morphology of glycyrrhetinic acid (PLGA) particles were observed by scanning electron microscope (SEM). The drug loading and encapsulation efficiency were measured and the drug release characteristics in vitro were compared. Results: the particle size was uniform, the morphology was controlled, the drug loading was high, and the external release of microsomes could be adjusted by changing the particle size and solvent system. Conclusion: the gel template method can accurately control the particle size and morphology, is suitable for a wide range of solvents, and is beneficial to the drug release regulation of the drug delivery system.
【作者单位】: 宁夏医科大学药学院;青海民族大学药学院;回医药现代化省部共建教育部重点实验室;宁夏回药现代化工程技术研究中心;
【基金】:国家自然科学基金(81360644) 宁夏回族自治区科技支撑国际合作项目(宁科计字[2013]21号)
【分类号】:R943

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