干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系

发布时间：2018-01-11 21:47

本文关键词：干预胆碱M受体对药物成瘾的影响及其与多巴胺的关系　出处：《心理科学进展》2016年08期 　论文类型：期刊论文

【摘要】：药物成瘾是一类精神及行为障碍,涉及到中枢神经系统的病变。毒蕈碱受体(Muscarinic receptor,M受体)属于胆碱能受体,分5种亚型。行为学研究表明,干预M受体能有效影响药物成瘾行为,但其神经机制还亟待探索。阿片类药物与精神活性药物均能激活中枢多巴胺系统,而M受体与多巴胺系统在多个脑区产生了交互作用。其中激动M2及M4受体抑制了多巴胺系统功能,而激动M5受体增强了多巴胺系统功能,与干预M2、M4、M5受体对药物成瘾行为的影响相对应。以上证据提示,干预M受体可能通过影响多巴胺系统对药物成瘾起作用。
[Abstract]:Drug addiction is a kind of mental and behavioral disorder, which is involved in central nervous system disease. Muscarinic receptor M receptor (muscarinic receptor M receptor) belongs to cholinergic receptor. Behavioral studies show that intervention of M receptor can effectively affect drug addiction behavior, but its neural mechanism needs to be explored. Both opioid drugs and psychoactive drugs can activate the central dopamine system. M receptor and dopamine system interact in many brain regions, in which activated M2 and M4 receptors inhibit the function of dopamine system, while activated M5 receptor enhance the function of dopamine system, and interfere with M2. The above evidence suggests that the intervention of M receptor may play an important role in drug addiction by affecting the dopamine system.
【作者单位】：首都师范大学心理系;
【基金】：国家自然科学基金项目(31470989)
【分类号】：B845.1
【正文快照】： 药物成瘾又称药物依赖、物质依赖,国际疾病及健康相关问题分类标准(International StatisticalClassification of Diseases and Related HealthProblems 10th Revision,ICD-10)将药物成瘾定义为一种精神及行为障碍。慢性使用阿片类药物或精神活性药物形成药物成瘾后,不仅对身

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