亲代孕前成瘾药物暴露对子代行为的影响及其表观遗传机制

发布时间：2018-02-28 17:26

  本文关键词： 成瘾药物 孕前 表观遗传 生殖细胞　出处：《心理科学进展》2017年10期 　论文类型：期刊论文

【摘要】：孕前成瘾药物暴露不仅危害使用者的身体健康,而且会对子代的生理行为造成影响,近年来研究发现表观遗传机制在其中发挥重要作用。孕前成瘾药物暴露会对子代的成瘾易感性和焦虑样行为造成影响,引起子代的抑郁样行为和认知受损。这些现象可能是成瘾药物通过引起亲代生殖细胞内表观遗传修饰变化所致,其中包括印记基因、神经递质系统、BDNF三个方面的表观遗传修饰变化。此外,未来除了加强以上三个方面基因的研究,也需要增加其他方面基因的研究,以及寻找能预测子代异常行为的表观遗传生物标志物。
[Abstract]:Exposure to prepregnancy addictive drugs not only harms the health of the user, but also affects the physical behavior of the offspring. In recent years, epigenetic mechanisms have been found to play an important role in this process. Exposure to prepregnancy addictive drugs may have an impact on susceptibility to addiction and anxiety like behavior in offspring. Depression-like behavior and cognitive impairment in offspring. These phenomena may be caused by addictive drugs that cause epigenetic modifications in parental germ cells, including imprinted genes. The epigenetic modification of BDNF in three aspects of the neurotransmitter system. In addition, in the future, in addition to strengthening the study of genes in these three areas, we also need to increase the research of other genes. And to find the epigenetic biomarkers that can predict the abnormal behavior of offspring.
【作者单位】： 中国科学院心理健康重点实验室中国科学院心理研究所;中国科学院大学;河北大学教育学院;
【基金】：河北省教育厅重点课题项目(SD151092)资助
【分类号】：B845.4
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本文编号：1548283