生理周期对女性大脑运动皮层可塑性的影响

发布时间：2018-10-12 16:50

【摘要】：研究目的:生理周期作为性别差异的一个重要表现,常常伴随着激体内激素种类和激素水平的变化,同时也会影响大脑的活动状态。可塑性是大脑的一个重要属性,受很多因素的影响。生理周期是否影响大脑皮层的可塑性,不同阶段对大脑皮层活动的影响是否有差异,目前还没有一致的定论。经颅磁刺激(TMS)技术是一种安全、无创的非侵入脑刺激技术,目前已经成为研究大脑皮层可塑性一个必不可少的手段,为了探究生理周期对大脑运动皮层可塑性的影响,本研究使用重复经颅磁刺激技术(rTMS)研究不同生理周期阶段对女性大脑皮层可塑性的影响。研究方法:选取南京师范大学的在校大学生47名(男性7名),根据生理周期将女性分为生理期组,卵泡期组和黄体期组,男性作为对照组。分别对男性和女性被试的左侧初级运动皮层(M1)施加1OHzrTMS和cTBS刺激方案,记录刺激前后运动诱发电位(MEP)的变化。结果:cTBS刺激大脑运动皮层引起生理期,卵泡期女性和男性对照组的MEP显著降低,而黄体期女性的MEP在刺激后则显著提高,而且与男性对照组差异显著(P0.05)。10HzrTMS刺激大脑运动皮层引起生理期和黄体期女性以及男性对照组的MEP振幅增加,但是与基线值没有显著差异(P0.05)。结论:TMS诱导大脑皮层可塑性受生理周期的影响,存在性别差异。不同生理周期阶段的皮层兴奋性不同。生理期的女性的皮层可塑性的变化与男性类似。
[Abstract]:Objective: as an important manifestation of gender differences, physiological cycle is often accompanied by changes in hormone types and hormone levels in the body, as well as affecting the state of brain activity. Plasticity is an important attribute of the brain and is influenced by many factors. Whether the physiological cycle affects the plasticity of the cerebral cortex, and whether there are differences in the effects of different stages on the cerebral cortex activity, there is still no consistent conclusion. Transcranial magnetic stimulation (TMS) is a safe, non-invasive and non-invasive brain stimulation technique, which has become an essential means to study cortical plasticity in order to explore the effects of physiological cycles on the plasticity of cerebral motor cortex. In this study, repeated transcranial magnetic stimulation (rTMS) was used to study the effects of different physiological cycles on cortical plasticity in women. Methods: 47 college students (7 males) from Nanjing normal University were divided into normal period group, follicular phase group and luteal phase group according to physiological cycle, and male as control group. The left primary motor cortex (M1) of male and female subjects were treated with 1OHzrTMS and cTBS respectively. The changes of (MEP) of motor evoked potential (MEP) were recorded before and after stimulation. Results: during the normal period induced by cTBS stimulation of cerebral motor cortex, MEP in follicular phase and male control group decreased significantly, while MEP in luteal phase increased significantly after stimulation. 10HzrTMS stimulation of cerebral motor cortex increased the amplitude of MEP in normal period and luteal phase of female and male control group, but there was no significant difference from baseline value (P0.05). Conclusion: the cortical plasticity induced by TMS is affected by physiological cycle. The cortical excitability is different at different physiological cycle stages. Changes in cortical plasticity in women during normal periods are similar to those in men.
【学位授予单位】：南京师范大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：B844.5

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