冲动性对不同成瘾行为发展的调控及其神经机制

发布时间：2018-11-10 20:07

【摘要】：近年来越来越多的研究证据提示,个体冲动性在成瘾疾患发生发展机制中具有关键作用,可能成为成瘾行为的潜在易感标记以及早期识别和干预的重要靶点,但冲动性对不同成瘾行为变化发展的调控机制尚不明确。项目拟综合跨成瘾谱系比较、纵向追踪设计、冲动行为干预等研究途径,采用人格测量、神经认知、神经影像等技术,首先比较尼古丁依赖者与网络游戏成瘾者的冲动性结构及其在前额叶纹状体环路的结构功能改变;然后采用混合分组设计筛选出具有高低冲动性的非成瘾青少年进行连续追踪研究,考察冲动性对尼古丁依赖与网络游戏成瘾的预测效力;并采用认知行为训练,对吸烟成瘾者与网络游戏成瘾者进行冲动干预,考察行为干预对冲动性水平及前额叶纹状体环路功能的改变,以及对不同成瘾行为发展的抑制后效。旨在探索冲动性作为成瘾的潜在易感标记及干预靶点的效力。
[Abstract]:In recent years, more and more research evidence suggests that individual impulsiveness plays a key role in the pathogenesis of addictive disorder, and may become a potential susceptibility marker of addictive behavior and an important target for early identification and intervention. However, the mechanism of impulsiveness regulating the change and development of different addictive behaviors is still unclear. The project was designed to integrate cross-addiction pedigree comparison, longitudinal tracking design, impulsive behavior intervention and other research approaches, using personality measurement, neurocognition, neuroimaging and other techniques. First, the impulsive structure of nicotine addicts and online game addicts and their structural and functional changes in the striatal loop of prefrontal lobe were compared. Then the non-addictive adolescents with high and low impulsiveness were selected by mixed group design to study the predictive effect of impulsiveness on nicotine dependence and online game addiction. Cognitive behavior training was used to conduct impulsive intervention on smokers and online game addicts to investigate the effects of behavioral intervention on the changes of impulsive level and the function of striatal loop in prefrontal lobe and the inhibition of the development of different addictive behaviors. The purpose of this study was to explore the efficacy of impulsiveness as a potential marker of addiction and an intervention target.
【作者单位】：贵州医科大学医学人文学院;贵州省健康发展研究中心;
【基金】：国家自然科学基金(31560284) 教育部人文社会科学研究青年基金项目(14YJC190022) 贵州省科学技术基金项目(黔科合J字[2014]2022号) 贵州省高校优秀科技创新人才支持计划(黔教合KY字[2015]485) 贵州省教育厅高等学校人文社会科学项目(JD2013083) 贵阳医学院博士基金项目(YJ2014-6)部分资助
【分类号】：B845.1

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