207例带状疱疹临床特征及预后因素分析

发布时间：2018-01-15 10:10

本文关键词：207例带状疱疹临床特征及预后因素分析　出处：《南京医科大学学报(自然科学版)》2017年11期 　论文类型：期刊论文

【摘要】：目的 :探讨带状疱疹的临床特征及预后因素。方法 :收集2008年1月—2015年12月住院确诊的207例带状疱疹患者的临床资料,对其发病年龄、性别、基础疾病、发病诱因、数字分级量表(numerical rating scale,NRS)评分、皮损分布与严重程度、实验室检查、治疗与预后进行回顾性分析,进一步利用Logistic回归分析对带状疱疹后遗神经痛的危险因素进行分析。结果:207例住院带状疱疹患者平均发病年龄(63.1±16.0)岁,发病无明显性别差异,17.4%患者合并2种以上基础疾病,51.2%患者发病前有明确诱因,60.4%患者具有前驱期疼痛,21.7%患者病程中伴有发热、皮损,以累及三叉神经眼支者最多,占36.7%;入院时NRS评分和皮损严重程度评分为中度或重度的患者占90%以上。治疗后19例发生带状疱疹后遗神经痛,1例遗留右上肢运动性麻痹。与同期门诊诊治的252例带状疱疹患者相比,住院带状疱疹患者带状疱疹后遗神经痛的发生率明显高于门诊患者(χ2=9.224,P0.01)。Logistic回归分析显示皮损累及胸神经分布区、NRS评分高是发生带状疱疹后遗神经痛的主要危险因素。结论:临床上应加强识别带状疱疹后遗神经痛的危险因素,早期进行规范与合理治疗。
[Abstract]:Objective: to investigate the clinical features and prognostic factors of herpes zoster. Methods: the clinical data of 207 cases of herpes zoster diagnosed in hospital from January 2008 to December 2015 were collected. The age, sex, basic disease, inducement, numerical rating scale (NRS) score, skin lesion distribution and severity were evaluated. Laboratory examination, treatment and prognosis were retrospectively analyzed. Logistic regression analysis was used to analyze the risk factors of postherpetic neuralgia. Results the mean onset age was 63.1 卤16.0 in #number0# patients with herpes zoster. Years old. There was no significant gender difference in the incidence rate of 17.4% patients with two or more basic diseases. 51.2% patients had definite inducement before onset. 60.4% patients had pain in the precursor phase. 21.7% patients with fever, skin lesions, the most involved in the trigeminal nerve ophthalmic branch, 36.7 percent; At the time of admission, more than 90% patients had moderate or severe NRS score and severity of skin lesions. After treatment, 19 patients developed postherpetic neuralgia. A case of left right upper limb motor palsy was compared with 252 cases of herpes zoster treated in outpatient clinic at the same time. The incidence of postherpetic neuralgia in patients with herpes zoster was significantly higher than that in outpatients (蠂 2 / 9.224). Logistic regression analysis showed that the area of thoracic nerve was involved in the lesion. High NRS score was the main risk factor for the occurrence of postherpetic neuralgia. Conclusion: the clinical risk factors of postherpetic neuralgia should be recognized and standardized and reasonably treated in the early stage.
【作者单位】：苏州大学附属第一医院皮肤科;
【基金】：江苏省自然科学基金青年基金(BK20140294)
【分类号】：R752.12
【正文快照】： 带状疱疹是皮肤科临床中的常见病,由水痘-带状疱疹病毒感染引起,常伴明显的神经痛,愈后可发生带状疱疹后遗神经痛。2008年1月—2015年12月本科共收治207例带状疱疹住院患者,现对其临床资料进行回顾性分析,并探讨发生带状疱疹后遗神经痛的危险因素。1对象和方法1.1对象收集2008

【相似文献】