TLR4、TGF-β1、CCL20在不同肝病患者肝组织内的表达差异性对比

发布时间：2018-01-16 08:34

本文关键词：TLR4、TGF-β1、CCL20在不同肝病患者肝组织内的表达差异性对比　出处：《中国地方病防治杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的通过检测慢性乙型病毒性肝炎(CHB)、肝硬化以及肝细胞癌(HCC)患者肝组织内TLR4、TGF-β1、CCL20的表达的变化,探讨TLR4、TGF-β1、CCL20参与CHB的发生和发展的相关机制。方法选取临床标本104例,并将其分为4个组,分别为正常对照组26例、CHB组26例、肝硬化组26例以及HCC组26例。采用免疫组织化学方法检测TLR4、TGF-β1、CCL20在各组中的表达。结果免疫组化结果显示,TLR4、TGF-β1、CCL20在CHB、肝硬化以及HCC组肝组织中的表达均明显高于正常对照组(P0.05)。TLR4和CCL20在HCC组的表达明显高于CHB组,差异有统计学意义(P0.05),肝硬化与HCC组的表达差异无统计学意义(P0.05)。TGF-β1在HCC组的表达明显高于肝硬化组和CHB组,差异均有统计学意义(P0.05)。结论肝病患者的TLR4、TGF-β1、CCL20的表达水平与正常人相比均升高,在CHB的发生和发展过程中发挥着重要作用。
[Abstract]:Objective to detect the expression of TLR4 and TGF- 尾 1 CCL20 in patients with chronic viral hepatitis B (CHB), liver cirrhosis and hepatocellular carcinoma (HCC). To explore the mechanism of TLR4 TGF- 尾 1 CCL20 involved in the occurrence and development of CHB. Methods 104 clinical specimens were selected and divided into 4 groups, 26 normal controls. CHB group (n = 26), cirrhosis group (n = 26) and HCC group (n = 26) were used to detect TGF- 尾 1 by immunohistochemical method. Results Immunohistochemical results showed that TLR4TGF- 尾 1 and CCL20 were present in CHB. The expression of P0.05TLR4 and CCL20 in liver cirrhosis and HCC group were significantly higher than those in HCC group. The expression of TLR4 and CCL20 in HCC group was significantly higher than that in CHB group. The difference was statistically significant (P0.05). There was no significant difference between liver cirrhosis group and HCC group. The expression of TGF- 尾 1 in HCC group was significantly higher than that in cirrhosis group and CHB group. Conclusion the expression of TLR4 and TGF- 尾 1 CCL20 in patients with liver disease is higher than that in normal controls. It plays an important role in the occurrence and development of CHB.
【作者单位】：焦作市人民医院;
【分类号】：R512.62;R575.2;R735.7
【正文快照】： 目前,慢性乙型病毒性肝炎、肝硬化以及肝细胞癌等肝病严重威胁着人类的身体健康[1]。关于Toll样受体(TLR4)信号传导途径、转化生长因子β1(TGF-β1)和CC型趋化因子20(CCL20)的表达与各种肝脏疾病发病之间的关系逐渐深入并成为研究热点[2-3]。本实验研究不同肝病患者的TLR4、TG

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