浙江省东部地区丙型肝炎病毒基因分型的研究

发布时间：2018-01-17 20:05

本文关键词：浙江省东部地区丙型肝炎病毒基因分型的研究　出处：《中华医院感染学杂志》2015年22期 　论文类型：期刊论文

【摘要】：目的比较分析浙江省东部地区不同时期丙型肝炎病毒(HCV)基因型的分布,为制定相应的防治策略提供参考。方法选择2008年1月-2013年4月就诊的338例慢性HCV感染者,分为早期组(2008年1月-2010年12月)231例和后期组(2011年1月-2013年4月)107例,采用基因芯片法进行HCV基因分型检测。结果 338例标本中共检出8种亚型,其中1a型、1b型、2a型、3a型、3b型、6型、1b+2a混合型、其他混合型,分别占1.18%、63.31%、11.84%、5.62%、5.92%、6.21%、4.74%、1.18%;两组中均以1b型为主要基因型,分别占70.13%和48.60%,但后期组1b型的构成比下降;2a型为早期组的次要基因型占10.82%,而6型为后期组的次要基因型占14.95%;早期组1b+2a混合型的构成比高于后期组(χ2=4.651,P=0.047),而1a型和6型的构成比均低于后期组(χ2=8.423和17.41,P0.001);男性患者在早期组混合型的构成比较高(χ2=6.270,P=0.012),而在后期组中为6型(χ2=13.553,P0.001);各基因型的年龄构成差异均无统计学意义。结论浙江省东部地区HCV基因型同样以1b型为主,但随着时间的推移,HCV基因型分布产生较大变化,其变化可能与人口流动和社会活动的增加相关。
[Abstract]:Objective to compare and analyze the distribution of hepatitis C virus (HCV) genotypes in eastern Zhejiang Province. Methods 338 patients with chronic HCV infection from January 2008 to April 2013 were selected. They were divided into early group (January 2008-December 2010) and late group (10 7 cases). Results there were 8 subtypes detected in 338 samples, including 1a, 1b, 2a, 3a, 3b and 6. 1b 2a mixed type, other mixed type, account for 1.18 and 63.31, respectively, about 11.84 and 5.62, and 5.92and 6.21, and 4.741.18; 1b genotype was the main genotype in both groups, accounting for 70.13% and 48.60, respectively, but the composition ratio of 1b genotype decreased in the latter group. The secondary genotype of type 2a was 10.82% in early group, while that of type 6 was 14.95% in anaphase group. The composition ratio of 1b2a mixed type in the early group was higher than that in the late stage group (蠂 2 + 4.651%). The composition ratios of type 1a and type 6 were lower than those of the later group (蠂 2 8.423 and 17.41 P 0.001). The composition of mixed type was higher in the early group (蠂 2 + 6.270) than in the later stage group (蠂 2 + 13.553% P 0.001). Conclusion 1b genotype is the main genotype in eastern Zhejiang Province, but the distribution of HCV genotype changes with time. The changes may be associated with increased population mobility and social activity.
【作者单位】：宁波市第二医院肝病中心;
【基金】：浙江省医坛新秀培养基金资助项目(2013-245) 宁波市自然科学基金资助项目(2010A610075) 宁波市优秀中青年卫生技术人才基金资助项目(2011-145) 宁波市领军和拔尖人才基金资助项目(2012-131)
【分类号】：R512.63
【正文快照】： 丙型肝炎病毒(hepatitis C virus,HCV)感染是全球慢性肝病的主要病因之一,而50.00%~80.00%的HCV感染者将进展为慢性状态,其中20.00%~30.00%的患者将发展为肝硬化或肝细胞癌(HCC)[1-2]。目前,HCV基因可分为1~6型6种基因型,每种基因型又分别可以分为多种基因亚型。本研究旨在通

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