3种不同剂量的青蒿琥酯抗小鼠细粒棘球蚴疾病作用的比较

发布时间：2018-01-17 22:14

本文关键词：3种不同剂量的青蒿琥酯抗小鼠细粒棘球蚴疾病作用的比较　出处：《中国人兽共患病学报》2015年01期 　论文类型：期刊论文

【摘要】：目的探讨高、中、低3种不同剂量青蒿琥酯体内抗包虫的作用。方法建立小鼠腹腔细粒棘球蚴疾病模型,随机分为4组,每天分别给与高(200mg/kg)、中(100mg/kg)、低(50mg/kg)3种剂量的青蒿琥酯注射液以及生理盐水,腹腔注射治疗3月后,观察小鼠体内包虫囊肿的外观发育情况、囊湿重、包虫囊壁的病理改变、电镜下超微结构的变化。结果中剂量组小鼠总囊重明显少于其他各组。中等剂量组抑囊率高于其他各组。病理及电镜发现3种剂量下包虫囊壁均有不同程度的破坏,其中中等剂量组囊肿中到重度破坏,角皮层纹理模糊,生发层细胞减少,甚至断裂,细胞核及线粒体溶解或退变。结论在相同的饲养条件下,中等剂量的青蒿琥酯注射液治疗小鼠腹腔细粒棘球蚴疾病的效果最佳。
[Abstract]:Objective to investigate the antihydatid effects of artesunate at high, medium and low doses in vivo. Methods mice models of intraperitoneal echinococcus granulosus disease were established and randomly divided into 4 groups. Each day, three doses of artesunate and saline were given to each of the three groups: high dose (200 mg / kg), middle dose (100 mg / kg), low dose (50 mg / kg) of artesunate and normal saline. After March, the patients were given intraperitoneal injection of artesunate or artesunate. The appearance and development of hydatid cyst in mice, the wet weight of cyst and the pathological changes of hydatid cyst wall were observed. Results the total cyst weight of mice in the middle dose group was significantly lower than that in the other groups, and the inhibition rate in the middle dose group was higher than that in the other groups. Bad. In the middle dose group, the cysts were destroyed moderately to severely, the keratinocytes were blurred, the germinal layer cells were decreased or even broken, and the nucleus and mitochondria were dissolved or degenerated. Conclusion under the same feeding conditions. The effect of middle dose artesunate injection on mice with intraperitoneal echinococcus granulosus disease was the best.
【作者单位】：石河子大学医学院第一附属医院肝胆外科;
【基金】：国家自然科学基金资助项目(No.81160199)~~
【分类号】：R532.32
【正文快照】： Funded by the National Natural Science Foundation of China(No.81160199)细粒棘球蚴病是威胁人类健康的全球性的寄生虫病,目前的治疗方法以手术治疗为主,药物治疗为辅。对于失去手术指征的患者,药物治疗是唯一的选择,因此关于药物治疗包虫病的研究一直备受关注。抗疟疾的

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