自体外周血干细胞移植对乙型肝炎肝硬化失代偿期吲哚氰绿滞留率的影响分析

发布时间：2018-01-20 01:22

本文关键词： 外周血干细胞肝硬化 ICG R 细胞移植乙型肝炎　出处：《中国现代医生》2016年36期 　论文类型：期刊论文

【摘要】：目的观察自体外周血干细胞移植治疗对乙型肝炎肝硬化失代偿期患者吲哚氰绿滞留率的影响。方法采用前瞻性、随机对照分组法,将60例乙型肝炎肝硬化失代偿期患者分成两组,每组30例,一组为移植组,在接受综合内科治疗的基础上接受自体外周血干细胞移植治疗,一组对照组,仅接受综合内科治疗。观察自体外周血干细胞移植后12周、24周、36周、48周症状和体征变化、血总胆红素(TBil)、凝血酶原活动度(PTA)、白蛋白(Alb)水平、吲哚氰绿15 min滞留率(ICG R15)的变化以及移植后的副反应、肿瘤发生率等,并与移植治疗前及同期对照组比较。结果外周血干细胞移植治疗后,大多数患者腹水等症状改善,未出现严重不良反应;移植后24周、36周、48周Alb水平、PTA与移植前及对照组比较,差异均有统计学意义(P0.01),移植后36周、48周ICG R15与移植前及12周比较,差异均有统计学意义(P0.05)。结论自体外周血干细胞移植治疗乙型肝炎肝硬化失代偿期患者安全、有效。
[Abstract]:Objective to observe the effect of autologous peripheral blood stem cell transplantation on the retention rate of indocyanine green in patients with hepatitis B cirrhosis in decompensated stage. Sixty patients with decompensated stage of hepatitis B cirrhosis were divided into two groups, 30 cases in each group. One group was treated with autologous peripheral blood stem cell transplantation on the basis of comprehensive medical treatment, and the other group was treated with autologous peripheral blood stem cell transplantation. After autologous peripheral blood stem cell transplantation, the changes of symptoms and signs, total bilirubin and Tbilirubin were observed 12 weeks and 24 weeks and 36 weeks and 48 weeks after transplantation. The changes of prothrombin activity, albumin Alb, 15 min retention rate of indocyanine green (ICGR15), side effects after transplantation, tumor incidence and so on. Results after peripheral blood stem cell transplantation, ascites and other symptoms of most patients were improved, and no serious adverse reactions were found. There were significant differences in Alb levels between 24 weeks and 36 weeks after transplantation and 36 weeks after transplantation compared with those before transplantation and control group, and 36 weeks after transplantation. There were significant differences in ICG R15 between 48 weeks and 12 weeks after transplantation. Conclusion Autologous peripheral blood stem cell transplantation is safe for patients with decompensated hepatitis B cirrhosis. Effective.
【作者单位】：宁波市第二医院肝病科;宁波市第二医院干细胞实验室;
【基金】：浙江省宁波市科技创新团队资助项目(2011B82016) 浙江省区域专病中心建设项目(第二批)(浙卫发〔2014〕98号)
【分类号】：R512.62;R575.2
【正文快照】： 目前内科治疗乙型肝炎肝硬化失代偿期效果欠佳,肝移植为较理想的治疗方法,但由于供体的紧缺限制了其临床应用[1]。近年来,干细胞移植治疗肝硬化的研究在国内外开展,但目前仍然缺少大样本的随机、对照研究[2,3],所以亟需一些大样本、随访时间较长的对照研究来进一步证实干细胞

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