流感病毒与金黄色葡萄球菌共感染致病机制研究进展

发布时间：2018-01-20 13:39

本文关键词： 流感金黄色葡萄球菌共感染致病机制　出处：《军事医学》2017年05期 　论文类型：期刊论文

【摘要】：近年研究表明,流感病毒与细菌共感染是导致流感流行期间高死亡率的重要原因。目前已报道能与流感发生共感染的细菌至少有12种,其中与金黄色葡萄球菌的共感染不仅最为常见,且致死率最高。流感病毒与金葡菌共感染除能诱发严重肺炎外,还能降低机体对病原或炎症损伤的耐受能力,而且此两种病原也能协同加重对机体的毒理损伤作用。该文结合近年来相关研究进展,对流感病毒/金葡菌共感染导致高死亡率的致病机制作一探讨,以期能对今后军队流感疫情防控及降低死亡率提供帮助。
[Abstract]:Recent studies have shown that co-infection of influenza viruses and bacteria is an important cause of high mortality during influenza epidemics. At least 12 species of bacteria have been reported to co-infect with influenza. Coinfection with Staphylococcus aureus is not only the most common, but also the highest fatality rate. The co-infection of influenza virus and Staphylococcus aureus can not only induce severe pneumonia, but also reduce the ability of tolerance to pathogenic or inflammatory injury. And these two pathogens can also increase the toxicological damage to the body. In this paper, the pathogenesis of high mortality caused by influenza virus / Staphylococcus aureus co-infection is discussed in the light of the related research progress in recent years. In order to help the army to prevent and control the influenza epidemic and reduce the mortality in the future.
【作者单位】：广西医科大学基础医学院;解放军疾病预防控制所传染病预防控制中心;
【基金】：国家重点研发计划资助项目(2016YFC1200905,2016YFC1200700) 国家自然科学基金资助项目(20873999)
【分类号】：R511.7;R515
【正文快照】： 自20世纪以来,全球每年仍有25万~50万人死于流感病毒感染[1],其中约2万人因并发细菌性肺炎而死亡[2,3]。目前认为能与流感病毒发生共感染的细菌至少有12种,最为常见的包括金黄色葡萄球菌(简称金葡菌,Staphylococcusaureus,S.aureus)、肺炎链球菌(Streptococcus pneumoniae)和

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