Treg和Th17细胞在寄生虫感染和卫生假说中的免疫调节

发布时间：2018-01-22 04:02

本文关键词： 寄生虫感染 Th细胞 Treg细胞免疫调节卫生假说　出处：《中国血吸虫病防治杂志》2017年01期 　论文类型：期刊论文

【摘要】：寄生虫感染在发展中国家仍然是一个严重威胁人类健康、影响社会经济发展的公共卫生问题。近年来,随着分子生物学和免疫学等研究进展,人们对寄生虫感染的免疫防御反应及免疫病理机制有了更多认识。CD4~+T细胞在机体免疫防御及免疫调节中发挥着非常重要的作用。传统上认为CD4~+T细胞在体内外可分化成Th1、Th2两大细胞亚群,它们产生不同的细胞因子,发挥不同功能。后来又发现了两种新的CD4~+T细胞亚群,即Th17细胞和调节性T(Treg)细胞。它们具有与传统的Th1、Th2细胞完全不同的、独立的分化和调节机制。已有大量研究证实,Treg和Th17细胞在寄生虫病的抗虫免疫及免疫病理机制中发挥着重要作用。此外,Th17和Treg细胞在寄生虫感染所诱导的卫生假说中的作用越来越受到重视。本文根据当前国内外有关Treg和Th17细胞分化及功能的研究进展,对Treg和Th17细胞在寄生虫感染及卫生假说中的作用作一简要综述。
[Abstract]:Parasite infection is still a serious threat to human health and social and economic development in developing countries. In recent years, with the development of molecular biology and immunology. There is more understanding of immune defense response and immunopathological mechanism of parasitic infection. CD4 ~ ~. T cells play a very important role in immune defense and immune regulation. Traditionally, CD4T cells can differentiate into Th1 in vivo and in vitro. Two large cell subsets of Th2 produced different cytokines and played different functions. Two new CD4T subsets were discovered later. That is, Th17 cells and regulatory Tory cells, which have completely different and independent differentiation and regulation mechanism from the traditional Th1Th 2 cells, have been confirmed by a large number of studies. Treg and Th17 cells play an important role in the anti-insect immunity and immunopathological mechanism of parasitic diseases. More and more attention has been paid to the role of Th17 and Treg cells in the hygiene hypothesis induced by parasitic infection. In this paper, the research progress on the differentiation and function of Treg and Th17 cells at home and abroad is reviewed. This paper reviews the role of Treg and Th17 cells in parasitic infection and hygiene hypothesis.
【作者单位】：江苏省血吸虫病防治研究所国家卫生和计划生育委员会寄生虫病预防与控制技术重点实验室江苏省寄生虫与媒介控制技术重点实验室江南大学公共卫生研究中心;
【基金】：国家自然科学基金(81373116) 江苏省公益院所能力提升项目(BM2015024)
【分类号】：R53
【正文快照】： CD4+T细胞由一系列具有不同功能的细胞亚群组成,包并具有不同的功能[1]。近年来,在研究不同种类CD4+T细胞的括辅助性T细胞(T helper cells,Th细胞)、调节性T细胞(Regu-功能、活化机制、表面标记物等方面均取得了较大进展。目前latory T cells,Treg细胞)、滤泡性T细胞(Follicul

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