男性慢性乙型肝炎患者肝细胞脂肪变危险因素分析

发布时间：2018-01-28 11:15

本文关键词： 慢性乙型肝炎肝脂肪变危险因素代谢综合征男性　出处：《实用肝脏病杂志》2014年02期 　论文类型：期刊论文

【摘要】：目的比较男性慢性乙型肝炎(CHB)合并肝脂肪变患者与单纯CHB患者临床特征,寻找影响肝细胞脂肪变的危险因素。方法 2010年3月~2013年3月期间,住院初治且有肝活检病理学检查的男性CHB患者209例,根据肝组织中有无脂质沉积分为CHB合并脂肪变组及单纯CHB组,比较两组患者血脂、血尿酸、血糖、饮酒、体质量指数和病毒载量情况,进行二元Logistic回归分析,了解肝脂肪变的危险因素。结果在209例男性CHB患者中,合并脂肪变121例(57.9%),单纯CHB 88例(42.1%);CHB合并脂肪变患者尿酸、低密度脂蛋白和甘油三酯分别为(352.5±87.1)mmol/L、(2.8±0.8)mmol/L和(1.8±0.1)μmol/L,均显著高于单纯CHB患者[(310.3±69.1)mmol/L、(2.2±0.6)mmol/L和(1.2±0.7)μmol/L,P0.01)];体质量指数和低密度脂蛋白水平升高是男性CHB患者合并肝脂肪变的危险因素(P0.05)。结论肥胖、血脂紊乱等代谢综合征相关表现是男性CHB患者肝组织脂肪变的危险因素,而饮酒或病毒载量可能不是肝脂肪变的危险因素。
[Abstract]:Objective to compare the clinical features between male patients with chronic hepatitis B (CHB) combined with hepatic adiposis and those with CHB alone. Methods from March 2010 to March 2013, 209 male CHB patients with liver biopsy pathological examination were hospitalized from March 2010 to March 2013. According to whether there was lipid deposition in liver tissue, the patients were divided into two groups: CHB combined with adiposis group and simple CHB group. The blood lipid, uric acid, blood glucose, alcohol consumption, body mass index and viral load were compared between the two groups. The risk factors of hepatic fatty degeneration were analyzed by binary Logistic regression analysis. Results among the 209 male patients with CHB, 121 cases were complicated with fatty degeneration (57.9%). CHB alone was found in 88 cases. Uric acid, low density lipoprotein and triglyceride were 352.5 卤87.1 mmol / L in patients with CHB complicated with adiposis, respectively. 2. 8 卤0. 8 mmol / L and 1. 8 卤0. 1 渭 mol / L were significantly higher than those in patients with CHB alone. [310.3 卤69.1 渭 mol / L, 2.2 卤0.6 渭 mol / L and 1.2 卤0.7 渭 mol / L, respectively. Body mass index (BMI) and low density lipoprotein (LDL) level were the risk factors of liver fatty change in male patients with CHB. The related manifestations of metabolic syndrome such as dyslipidemia are the risk factors of hepatic steatosis in male patients with CHB, while alcohol consumption or viral load may not be the risk factors of hepatic steatosis.
【作者单位】：新疆医科大学第一附属医院肝病科;
【基金】：新疆维吾尔自治区科技支撑项目(编号:201141137) 国家自然科学基金资助项目(编号:81360138)
【分类号】：R512.62
【正文快照】： 随着肥胖、代谢综合征及其相关脂肪肝发病率的不断增高,慢性乙型肝炎(chronic hepatitis B,CHB)合并肝脂肪变愈来愈常见[1]。目前研究多分别针对CHB或非酒精性脂肪性肝炎(non-alcoholic steatohepatitis,NASH),而对CHB合并肝脂肪变的情况则研究较少。本文分析了209例初治的男

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