四川人群丙肝病毒基因型分布及与抗病毒疗效的相关性

发布时间：2018-01-28 19:37

本文关键词： 丙肝病毒基因型四川人群治疗学　出处：《四川大学学报(医学版)》2015年04期 　论文类型：期刊论文

【摘要】：目的调查四川地区丙肝病毒基因型的分布,探讨其与抗病毒疗效及疾病相关因素之间的关系。方法对189例就诊于四川大学华西医院的丙肝患者进行基因型调查,并在聚乙二醇干扰素α-2a联合利巴韦林抗病毒治疗前后的多个时间点对血清病毒载量进行测定,分析抗病毒治疗应答率,同时测定基线血清天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平。结果四川地区共发现4种HCV基因型,存在9种基因亚型,基因型以HCV-1型为主,占79.89%(151/189),其中1b型占78.84%;非HCV-1型感染者占20.11%(38/189)。HCV-1型感染者的治疗结束时病毒学应答(ETVR)率及早期病毒学应答(EVR)率低于非HCV-1型(分别为65.56%vs.84.21%,52.98%vs.76.32%,P0.05);不同HCV基因型感染者的基线血清病毒载量及基线肝功能指标水平之间的差异并无统计学意义。结论四川地区丙肝患者中以HCV-1型感染者最多。证实HCV基因型是四川地区丙肝患者重要的抗病毒治疗疗效的预测因素。
[Abstract]:Objective to investigate the distribution of HCV genotypes in Sichuan. Methods the genotypes of 189 patients with hepatitis C were investigated in Huaxi Hospital of Sichuan University. The serum viral load was measured at several time points before and after treatment with pegylated interferon 伪 -2a and ribavirin, and the response rate of antiviral therapy was analyzed. The serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (alt) were determined simultaneously. Results four HCV genotypes were found and 9 subtypes were found in Sichuan. The genotype of HCV-1 was the main type, accounting for 79.89% of 1891%, of which 1b type accounted for 78.84%. Non-type HCV-1 infection accounted for 20.11% of patients with 38 / 189% HCV-1 infection: ETVRR rate at the end of treatment and early virology response (EVRR). The rate was lower than that of non-#en0# type (65.56 vs 84.21%, respectively). 52.98 v. 76.32% P0.05; There was no significant difference in baseline serum viral load and baseline liver function between different HCV genotypes infected patients. HCV-1 genotype was the most common infection in hepatitis C patients in Sichuan area. It was confirmed that HCV genotype was an important predictor of antiviral therapeutic effect in hepatitis C patients in Sichuan area.
【作者单位】：四川大学华西医院实验医学科;
【正文快照】： 丙型肝炎病毒(hepatitis C virus,HCV)引起的丙型病毒性肝炎呈全球性流行,并逐年增加。根据HCV基因组核苷酸序列差异程度,可将HCV分为6种基因型和多种亚型,在中国流行的HCV亚型以1b(66%)和2a(14%)型为主,1b型最为流行。目前中国西部及西南地区的HCV基因型分布鲜有报道,此前有

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