长汀县结核病耐药监测分析

发布时间：2018-01-28 21:49

本文关键词： 肺结核耐药监测药物敏感性试验　出处：《海峡预防医学杂志》2016年06期 　论文类型：期刊论文

【摘要】：目的了解长汀县国家耐药监测点耐药结核病流行状态。方法根据《全国结核病耐药性基线调查实施手册》的患者纳入原则,2013—2015年长汀县CDC结核病防治门诊连续纳入涂阳肺结核患者158例,对患者痰标本分离培养获得的152株阳性菌株进行9种药物(一线:H、R、S、E;二线:K、O、C、P、TH1321)药敏试验和对硝基苯甲酸Mtb菌型鉴定。结果监测3年结核分枝杆菌总耐药率23.0%,总耐多药率3.3%,总广泛耐药率为0.7%。总耐药率低于全国平均水平,与福建省平均水平类似,总耐多药率均低于国家和福建省平均水平。结论长汀县的结核病控制策略执行得力,对于广泛耐药结核病,将在监测中予以重点关注,以控制结核病耐药趋势。
[Abstract]:Objective to understand the prevalence of drug-resistant tuberculosis in national drug resistance monitoring points in Changting County. Methods according to the implementation Manual of the National baseline Survey of Drug Resistance, the patients were included in the principles. From 2013 to 2015, 158 cases of smear positive pulmonary tuberculosis were included in CDC TB control outpatient clinic of Changting County. Nine kinds of drugs were used to isolate 152 positive strains from sputum samples of patients. Results the total drug resistance rate of Mycobacterium tuberculosis was 23.0 and the total multi-drug resistance rate was 3.3% for 3 years. The total drug resistance rate was 0.7.The total drug resistance rate was lower than the national average level, which was similar to the average level in Fujian Province. Conclusion the strategy of TB control in Changting County is effective in carrying out the control strategy. In order to control the trend of drug resistance of TB, we should pay more attention to it in the surveillance of XDR-TB.
【作者单位】：龙岩市疾病预防控制中心;长汀县疾病预防控制中心;
【分类号】：R52
【正文快照】： 耐药结核病的产生和流行是当前面临的难题,尤其是耐多药结核病,在许多国家已成为重要的公共卫生问题。已证实规范治疗对所有类型肺结核病切实可行,且成本效益比高;未经治疗或不规范治疗,将使耐药肺结核病患者不断产生[1]。长汀县2008年参加全国结核病耐药性基线调查,2013年起

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