武汉市普通人群戊型肝炎血清学及影响因素分析

发布时间：2018-02-02 02:56

本文关键词： 肝炎病毒戊型健康调查血清流行病学危险因素　出处：《中华疾病控制杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的评估武汉市普通人群戊型病毒性肝炎病毒(戊型肝炎病毒,hepatitis E virus,HEV)感染状况及影响因素。方法采用多阶段随机抽样方法,对抽取的3 890名0~59岁普通人群开展调查与血样采集,应用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)检测抗-HEV IgG,采用χ~2检验、精确二项式公式法与非条件Logistic回归等方法进行统计学分析。结果武汉市0~59岁普通人群抗-HEV IgG标化阳性率为35.01%,男性标化阳性率与女性的差异无统计学意义(χ~2=3.18,P=0.075),随着年龄增长阳性率升高(χ~2=542.32,P0.001),城区人群标化阳性率高于郊区(χ~2=11.32,P=0.001);18岁以上人群抗-HEV IgG多因素分析显示,男性、年龄较大者(30~59岁)、居住于城区、喜食鱼类的人群感染HEV的风险更高(均有P0.05)。结论武汉市普通人群HEV感染率较高,男性、年龄较大者(30~59岁)、居住于城区、喜食鱼类的居民是高危人群。
[Abstract]:Objective to evaluate hepatitis E virus in the general population of Wuhan. Methods A multi-stage random sampling method was used to investigate and collect blood samples from 3 890 ordinary people aged 0 59 years old. Enzyme linked immunosorbent Elisa was used to detect anti-HEV IgG and 蠂 2 test was used. Results the standardized positive rate of anti-HEV IgG was 35.01% in the general population aged 0 to 59 years in Wuhan. There was no significant difference between male and female in standardized positive rate (蠂 ~ 2 / 2 / 3.18). The positive rate increased with the increase of age (蠂 ~ (2 / 2) ~ (2) 2 / 32 ~ (2) P ~ (0.001)). The standardized positive rate in urban population was higher than that in suburban area (蠂 2 + 11.32% P < 0.001). The multivariate analysis of anti-HEV IgG in the population over 18 years old showed that male, aged 30 to 59 years old, lived in urban area. Conclusion the infection rate of HEV in the general population of Wuhan is higher than that in the other groups. The male, the older group is 30 years old and 59 years old, living in the urban area, and the risk of infection is higher (P0.055.Conclusion the infection rate of HEV is higher in the general population of Wuhan. Fish-eating residents are at high risk.
【作者单位】：武汉市疾病预防控制中心传染病防制所;武汉市皮肤病防治研究所医务科;
【基金】：湖北省自然科学基金(2011CDC124) 武汉市人力资源和社会保障局2014年度创新人才开发资金资助重点项目(2014年)
【分类号】：R512.6
【正文快照】： 戊型病毒性肝炎(简称戊型肝炎)是由戊型肝炎病毒(hepatitis E virus,HEV)感染引起的急性病毒性肝炎,主要经粪-口途径传播,在人群中可呈暴发、流行或散发。戊型肝炎急性感染病例主要发生于15~40岁年轻人群且症状较轻,但孕妇感染后病死率可达10%~40%[1]。目前已公认戊型肝炎是

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