参苓白术散加减联合恩替卡韦治疗慢性乙型肝炎对HBsAg定量的影响

发布时间：2018-02-03 22:01

本文关键词： HBsAg定量慢性乙型肝炎中医药治疗参苓白术散加减　出处：《辽宁中医杂志》2015年10期 　论文类型：期刊论文

【摘要】：目的:参苓白术散加减联合恩替卡韦治疗慢性乙型肝炎对HBs Ag定量的影响。方法:选择70例慢性乙型肝炎采用恩替卡韦分散片抗病毒患者,随机分为治疗组35例,对照组35例。治疗组在基本治疗基础上,给予参苓白术散加减治疗。24周后进行疗效评价。随访24周。结果:治疗组与对照组相比,丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、γ-谷氨酰转肽酶(GGT)、血清总胆红素(TBIL)、直接胆红素(DBIL)、碱性磷酸酶(ALP)无显著性差异,治疗24周、随访24周HBs Ag定量变化有显著差异。结论:参苓白术散加减联合恩替卡韦治疗慢性乙型肝炎,HBs Ag定量有较明显下降。提示益气健脾中药对慢性乙肝患者治疗有重要意义,值得进一步研究。
[Abstract]:Objective: to study the effect of Shenling Baizhu Powder plus or minus entecavir on HBs Ag in patients with chronic hepatitis B. methods: 70 patients with chronic hepatitis B were treated with entecavir dispersible tablets. They were randomly divided into treatment group (n = 35) and control group (n = 35). The therapeutic effect was evaluated after treatment with Shenling Baizhu Powder for 24 weeks. The follow-up was 24 weeks. Results: compared with the control group, alanine aminotransferase (alt) was used in the treatment group. Aspartate aminotransferase (AST), 纬 -glutamyl transpeptidase (GGT), serum total bilirubin (TBILL), direct bilirubin (DBIL). There was no significant difference in alkaline phosphatase (ALP). The quantitative changes of HBs Ag were significantly different after 24 weeks of treatment and follow up for 24 weeks. Conclusion: Shenling Atractylodes Powder plus or minus combined with entecavir in the treatment of chronic hepatitis B. The quantitative value of HBs Ag was obviously decreased, which suggested that Chinese herbal medicine for invigorating qi and invigorating spleen was of great significance in the treatment of chronic hepatitis B patients, and was worthy of further study.
【作者单位】：十堰市中医医院肝病科;
【基金】：湖北省十堰市科学技术局科技计划项目14K71(十科发[2014]15号)
【分类号】：R512.62
【正文快照】： 随着对乙型肝炎病毒(hepatitis B virus,HBV)血清表面抗原(HBs Ag)意义的重新认识而发展起来的HBs Ag定量检测技术日益成熟,其临床应用价值也被人们关注。慢性HBV感染自然史的不同阶段HBs Ag水平不同。中药治疗慢性乙型肝炎已经取得一定成果,如抗病毒、改善患者各种临床症状、

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