系统性红斑狼疮合并结核的临床特征和相关因素分析

发布时间：2018-02-08 19:19

本文关键词： 系统性红斑狼疮活动性结核肺结核肺外结核　出处：《实用医学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的探讨系统性红斑狼疮(SLE)患者合并结核的临床特点及相关因素。方法回顾性分析42例SLE合并结核患者的临床特点、治疗及预后。结果 782例SLE住院患者中,共有42例患者(5.4%)发生活动性结核,其中17例肺结核,11例肺结核合并肺外结核,14例肺外结核。胸片异常见于34例(81.0%)患者,19例为多肺叶受累,9例累及单个肺叶。共有23例(54.8%)肺部病变位于肺中下叶或为粟粒性结节。多因素回归分析显示贫血(OR=2.7,95%CI=1.2~6.2,P=0.02)及糖皮质激素的日均剂量(OR=1.03,95%CI=1.01~1.06,P=0.02)是SLE合并活动性结核的危险因素。结论 SLE患者合并活动性结核临床表现不典型。贫血与糖皮质激素的日均剂量与活动性结核的发生相关。
[Abstract]:Objective to investigate the clinical features and related factors of tuberculosis in patients with systemic lupus erythematosus (SLE). Methods the clinical characteristics, treatment and prognosis of 42 patients with SLE complicated with tuberculosis were retrospectively analyzed. A total of 42 patients developed active tuberculosis. Of them, 17 cases had pulmonary tuberculosis, 11 cases had pulmonary tuberculosis and 14 cases had extrapulmonary tuberculosis. Chest radiographs were abnormal in 34 cases.) 19 cases had multiple lobes involvement 9 cases involved single lobes. 23 cases were located in the middle and lower lobes of the lung or 54.8% of them were located in the middle and lower lobes of the lung. Multivariate regression analysis showed that the risk factors of SLE complicated with active tuberculosis were the daily average dose of OR1. 0395) and glucocorticoid. Conclusion the clinical manifestations of SLE patients with active tuberculosis are not typical. The daily average dose of corticosteroids is associated with the occurrence of active tuberculosis.
【作者单位】：中山大学附属第一医院风湿免疫科;中山大学附属第一医院老年病科;中山大学附属第一医院内科门诊;
【基金】：国家自然科学基金资助项目(编号:81603435,81601403) 广东省科技计划项目(编号:2014A020221009,2016A020215043)
【分类号】：R52;R593.241

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