益血生胶囊联合西药治疗慢性丙型病毒性肝炎40例临床观察

发布时间：2018-02-09 14:44

本文关键词： 慢性丙型病毒性肝炎干扰素α 利巴韦林益血生胶囊骨髓抑制　出处：《中医杂志》2015年16期 　论文类型：期刊论文

【摘要】：目的观察益血生胶囊联合聚乙二醇化干扰素α-2a(PEG-IFNα-2a)、利巴韦林片治疗慢性丙型病毒性肝炎的临床疗效。方法 80例慢性丙型病毒性肝炎患者采用随机数字表法分为治疗组和对照组各40例,均给予PEG-IFNα-2a(每次180μg,皮下注射,每周1次)以及利巴韦林片(每次300 mg,口服,每天3次)治疗,疗程6个月。治疗组在此治疗的首3个月,加用益血生胶囊口服,每次1 g,每天3次。两组患者治疗结束后随访6个月。观察治疗前后两组患者血清丙氨酸氨基转移酶水平、丙型肝炎病毒定量、中性粒细胞计数、血红蛋白含量、血小板计数的变化,比较两组患者生化学应答及病毒学应答百分比及骨髓抑制发生率。结果两组患者治疗3、6个月及随访6个月时病毒学应答比较差异均无统计学意义(P0.05);两组患者治疗6个月及随访6个月生化学应答比较差异亦无统计学意义(P0.05);治疗3、6个月时,治疗组的骨髓抑制发生率分别为35.00%及22.50%,均低于对照组的80.00%与60.00%(P0.01)。结论伍用益血生胶囊可减少PEG-IFNα2a、利巴韦林片治疗慢性丙型病毒性肝炎患者的骨髓抑制作用,但未能提高抗病毒疗效。
[Abstract]:Objective to observe the clinical effect of Yixuesheng capsule combined with PEG-IFN- 伪 -2aHG and ribavirin tablets in the treatment of chronic viral hepatitis C. methods 80 patients with chronic viral hepatitis C were divided into two groups by random digital table method. There were 40 cases in each group and 40 cases in control group. All patients were given PEG-IFN 伪 -2a (180 渭 g each time, once a week) and ribavirin tablets (300mg each time, 3 times a day) for 6 months. The treatment group was treated with Yixuesheng capsule for the first 3 months. The patients in the two groups were followed up for 6 months after treatment. The levels of serum alanine aminotransferase (alt), hepatitis C virus (HCV), neutrophil count and hemoglobin content were observed before and after treatment. Changes in platelet count, The percentage of biochemical and virological responses and the incidence of bone marrow suppression were compared between the two groups. Results there was no significant difference in virological response between the two groups at 3 months, 6 months and 6 months follow-up. There was no significant difference in biochemical response between 6 months and 6 months follow-up, and at 3 and 6 months after treatment, there was no significant difference in biochemical response. The incidence of bone marrow suppression in the treatment group was 35.00% and 22.50, respectively, which was lower than that in the control group (80.00% and 60.001). Conclusion the combined use of Yixuesheng capsule can reduce the bone marrow suppression effect of PEG-IFN 伪 2a and ribavirin tablets in the treatment of chronic hepatitis C, but it does not improve the antiviral effect.
【作者单位】：厦门大学医学院;厦门市中医院;
【基金】：福建省卫生厅青年科研课题(2012-2-105)
【分类号】：R512.63

【参考文献】