黄连滴眼液雾化联合复方萘甲唑啉滴眼液对过敏性结膜炎的疗效观察

发布时间：2018-02-12 17:06

本文关键词： 黄连滴眼液过敏性结膜炎中药超声雾化　出处：《广东医学》2017年22期 　论文类型：期刊论文

【摘要】：目的观察黄连滴眼液雾化联合复方萘甲唑啉滴眼液治疗各种过敏性结膜炎的临床效果及炎症因子的表达改变。方法选择60例过敏性结膜炎患者,按就诊时间随机分为两组:观察组30例,应用黄连滴眼液雾化联合复方萘甲唑啉滴眼液点眼;对照组30例,应用生理盐水雾化联合复方萘甲唑啉滴眼液点眼,频率为4次/d,观察组和对照组分别治疗7 d后复诊。评判治疗前后患者症状体征的改变以及采用ELISA法检测治疗前后患者泪液中IL-1β的表达情况。结果观察组和对照组患者的总有效率(治愈及显效)在治疗后分别为86.6%(26/30)和56.6%(17/30),差异有统计学意义(X~2=6.648,P=0.010)。取部分过敏性结膜炎患者泪液,检测发现IL-1β的表达量在经过治疗后表达量均下降,且观察组较对照组下降程度更为明显,两组比较差异有统计学意义(P0.05)。结论复方萘甲唑啉滴眼液联合黄连滴眼液雾化治疗对过敏性结膜炎患者症状与体征的缓解作用较单用复方萘甲唑啉滴眼液更为明显,值得临床推广。
[Abstract]:Objective to observe the clinical effect and the expression of inflammatory factors in the treatment of various allergic conjunctivitis by atomization of Huanglian eye drops and compound naphthazoline eye drops. Methods 60 patients with allergic conjunctivitis were selected. The patients were randomly divided into two groups according to the time of visit: the observation group (n = 30) was treated with Huanglian eye drops and compound naphthazoline eye drops, and the control group (n = 30) with normal saline atomization and compound naphthazoline eye drops. The frequency was 4 times / d. The observation group and the control group were treated for 7 days respectively. The changes of symptoms and signs of the patients before and after treatment and the expression of IL-1 尾 in the tear before and after treatment were evaluated by ELISA method. Results the expression of IL-1 尾 in the patients' tears before and after treatment was detected by ELISA method. The total effective rate (cure and remarkable effect) after treatment was 86. 660 / 30 and 56. 6 / 30, respectively. The difference was statistically significant. The tears of some allergic conjunctivitis patients were taken from the patients with hypersensitive conjunctivitis. It was found that the expression of IL-1 尾 decreased after treatment, and the decrease was more obvious in the observation group than in the control group. Conclusion the effect of compound naphthazoline eye drops combined with Huanglian eye drops on the relief of symptoms and signs in patients with allergic conjunctivitis is more obvious than that of compound naphthazoline eye drops alone. It is worth popularizing in clinic.
【作者单位】：广东省中医院眼科;
【分类号】：R777.31

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