男性尖锐湿疣患者HPV基因型、流行病学特征及转归

发布时间：2018-02-14 10:33

本文关键词： 尖锐湿疣男性 HPV基因型流行病学转归　出处：《中国皮肤性病学杂志》2017年05期 　论文类型：期刊论文

【摘要】：目的了解从化地区男性尖锐湿疣(CA)患者HPV基因型、流行病学特征及临床转归情况。方法采用PCR-反向点杂交法对307例男性CA患者行HPV基因检测,并记录个人史,治疗结束后6个月未复发者结束随访,并判定转归。结果 307例男性CA患者中,281例HPV(+)。低危型HPV(+)91.81%(258/281),以HPV 6,11居多,高危型HPV(+)47.69%(134/281),以HPV 52,16居多。HPV单一感染152例(低危型HPV 132例,高危型HPV 20例)。HPV混合感染129例(高-高型3例,低-低型15例,高-低型111例)。各年龄段之间高危型HPV(+)差异无统计学意义(P0.05),HPV混合感染者较HPV单一感染者更易携带高危型HPV(P0.01)。21~30岁高发,后随着年龄增长其逐渐降低。55例(31.98%,55/172)复发,26例临床治愈患者复查HPV基因型,5例阳性。结论本地区男性CA患者低危型HPV以HPV 6,11居多,高危型以HPV 52,16居多。好发于21~30岁人群,多数有不洁性生活史,应加强对该人群HPV及尖锐湿疣知识宣传,从而降低CA发病率。
[Abstract]:Objective to investigate the HPV genotype, epidemiological characteristics and clinical outcome of male condyloma acuminatum (CA) patients in Conghua area. Methods the HPV gene was detected by PCR-reverse dot hybridization in 307 male patients with CA, and their personal history was recorded. Results out of 307 male patients with CA, 281 were found to be HPV.Low-risk HPVs (91.81 / 281), most of which were HPV 611, high-risk HPVs (47.69% 134p 281), and HPV 52m16 was the most common type. 152 cases were single HPVinfection (low risk type HPV 132 cases). There were 20 cases of high risk HPV with mixed infection (3 cases of high-high type, 15 cases of low-low type), 12 cases of high-high type of HPV and 15 cases of low-low type of HPV. There was no significant difference in high risk HPV (HPVs) between different age groups. High risk HPV(P0.01).21~30 was more likely to be carried in mixed HPV-infected patients than in single HPV patients. With the increase of age, it gradually decreased. 55 cases of recurrence and 26 cases of clinical cured patients were diagnosed as HPV genotype positive. Conclusion the low risk type HPV of male CA patients in this area is mostly HPV 6 / 11, and high risk type is HPV 52P 16. It is good for 21 to 30 years old people. Most of them had a history of unclean sex life. We should strengthen the propaganda of HPV and condyloma acuminatum so as to reduce the incidence of CA.
【作者单位】：南方医科大学第五附属医院皮肤科;
【基金】：广东省医学科研基金(A2014139)
【分类号】：R752.53

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