ErbB2基因rs1058808位点多态性与延边地区HBV相关肝细胞肝癌的关系及民族差异

发布时间：2018-02-22 05:32

本文关键词： 肝细胞肝癌 ErbB 基因多态性乙型肝炎病毒民族差异延边　出处：《山东医药》2017年10期 　论文类型：期刊论文

【摘要】：目的观察延边地区乙型肝炎病毒(HBV)相关肝细胞肝癌(HCC)患者ErbB2基因rs1058808位点多态性,探讨rs1058808位点多态性与HBV相关HCC的关系及民族差异。方法选取66例(朝鲜族28例、汉族38例)HBV相关HCC患者(病例组)和150例(朝鲜族68例、汉族82例)单纯HBV携带者(对照组),采用双脱氧链末端终止法检测ErbB2基因rs1058808位点多态性,并分析两组及不同民族基因型和等位基因的分布情况。结果病例组ErbB2基因rs1058808位点的CC、CG和GG基因型所占比例分别为15.2%、46.9%、37.9%,对照组分别为14.7%、62.7%、22.7%,观察组GG基因型所占比例高于对照组(P0.01)。病例组朝鲜族和汉族人群ErbB2基因rs1058808位点GG基因型所占比例分别为35.7%、36.8%,均高于对照的23.5%、22.0%(P均0.01);两组同民族CC、CG基因型及C、G等位基因分布差异无统计学意义,病例组汉族和朝鲜族人群CC、CG和GG基因型及C、G等位基因分布差异无统计学意义(P均0.05)。结论 ErbB2基因rs1058808位点GG基因型可能是延边地区人群HBV相关HCC发生的主要遗传易感因素,且汉族和朝鲜族间不存在民族差异。
[Abstract]:Objective to observe the rs1058808 polymorphism of ErbB2 gene in patients with hepatitis B virus (HBV) associated hepatocellular carcinoma (HCC) in Yanbian area, and to explore the relationship between rs1058808 locus polymorphism and HBV related HCC. Methods 66 cases (28 Korean) were selected. The polymorphism of rs1058808 locus of ErbB2 gene in 38 patients with HBV-associated HCC in Han nationality (case group) and 150 patients (68 Korean, 82 Han) with simple HBV carrier (control group) was detected by dideoxychain termination method. The distribution of genotype and allele of ErbB2 gene in two groups and different nationalities were analyzed. Results the proportions of rs1058808 locus and GG genotype of ErbB2 gene in the case group were 15.226.9% and 37.9%, respectively, while those in the control group were 14.72.72.70.The proportion of GG genotype in the observation group was higher than that in the control group. The proportion of GG genotypes of ErbB2 gene rs1058808 locus in Korean and Han population was 35.778, respectively, which was higher than that in the control group (23.50.22. 0%), and there was no significant difference between the two groups in the distribution of rs1058808 genotype and CGG allele between the two groups. There was no significant difference in the distribution of CCG and GG genotypes and Cogg alleles between Han and Korean population. Conclusion the GG genotype at rs1058808 locus of ErbB2 gene may be the main genetic susceptibility factor of HBV related HCC in Yanbian population. There is no ethnic difference between Han nationality and Korean nationality.
【作者单位】：延边大学附属医院;延边大学医学院;
【基金】：国家自然科学基金资助项目(81560400) 吉林省教育厅“十二五”科学技术研究项目(2013-13)
【分类号】：R735.7;R512.62

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