阿米替林联合卡马西平治疗带状疱疹后神经痛的疗效与安全性

发布时间：2018-02-22 16:47

本文关键词： 卡马西平阿米替林带状疱疹后神经痛临床疗效安全性　出处：《中国药房》2015年33期 　论文类型：期刊论文

【摘要】：目的:观察阿米替林联合卡马西平治疗带状疱疹后神经痛(PHN)的疗效与安全性。方法:将80例PHN患者随机均分为观察组和对照组。对照组患者口服卡马西平片100 mg,bid,3 d后剂量增加至100 mg,tid。观察组患者在对照组治疗的基础上加用阿米替林片12.5 mg,每晚睡前口服,d1~3;3 d后剂量增加至25 mg,每晚睡前口服,d4~5;第6天起每日晨起口服12.5 mg+每晚睡前口服25 mg。两组患者用药期间均可根据患者的疼痛及药物不良反应调整用药剂量,疗程均为4周。观察两组患者治疗后的视觉模拟评分法(VAS)评分、睡眠时间、疼痛消失时间与总有效率,并记录不良反应发生情况。结果:观察组患者的总有效率显著高于对照组,VAS评分显著低于对照组,睡眠时间显著长于对照组,疼痛消失时间显著短于对照组,差异均有统计学意义(P0.05)。两组患者不良反应发生率比较,差异无统计学意义(P0.05)。结论:阿米替林联合卡马西平治疗PHN的疗效显著,安全性较好。
[Abstract]:Objective: to observe the efficacy and safety of amitriptyline combined with carbamazepine in the treatment of postherpetic neuralgia. Methods: 80 patients with PHN were randomly divided into observation group and control group. The dosage of Amitriptyline tablet was 12.5 mg on the basis of treatment in the control group, and the dosage of Amitriptyline tablet was increased to 25 mg 3 days after 3 days before bedtime, and 5 mg / d before bedtime every night, and 12.5 mg daily from the 6th day onwards. Two groups of patients can adjust the dosage according to the pain and adverse drug reaction. The course of treatment was 4 weeks. Visual analogue score (VAS), sleep time, time of pain disappearance and total effective rate were observed. Results: the total effective rate of the patients in the observation group was significantly higher than that in the control group and the score of VAS was significantly lower than that in the control group, the sleep time was significantly longer than that in the control group, and the time of pain disappearance was significantly shorter than that in the control group. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion: amitriptyline combined with carbamazepine is effective and safe in the treatment of PHN.
【作者单位】：浙江仙居县人民医院神经内科;浙江仙居县人民医院皮肤科;
【分类号】：R752.12

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